Calecim

Calecim Professional Serum.

Serums

About this product

A serum containing proteins, peptides, growth factors, and exosomes derived from deer umbilical cord, designed to target fine lines, skin texture, brightness, and support collagen production and skin repair.

Full ingredients

Ptt-6®, (Stem Cell Derived Fibronectins, Glycoproteins, Albumin, Collagens, Hyaluronic Acid) Aqua, Hyaluronic Acid, Glycoproteins, 1,2-Hexanediol, Soluble Collagen, Albumen, Fibronectin

Guru Score

90%

Yay

3 experts · Moderate agreement

What the gurus are saying

A little goes a long way with this serum, so one drop spreads across the face without needing much product at all. The gurus who tested it found it calms skin quickly, repairs visibly, and helps skin stay resilient over time, with effects on fine lines, texture, and brightness. Best applied to well-exfoliated skin so it can penetrate deeply, and you may want to start with once or twice a week rather than daily to see how your skin responds.

Synthesized from 3 expert reviews · most recent take September 2026

What they liked

Calms and repairs skin quickly
A little goes a long way
Spreads easily, works by the drop

What they flagged

Needs exfoliated skin to penetrate well

Best for

Mature skin

Type

SerumsDrops & dropper

Key actives

Hyaluronic acid

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

No BS Beauty

89k subs

✓Mixed

"So these are expensive. $100 for five milliliters, making it one of the if not the most expensive skincare product I've ever reviewed for a tiny amount. But a couple drops do a good job covering most of the skin and feel nice, but it is expensive. You can get the six-pack, which kind of brings [...] the average price per bottle down, but it is expensive. [...] This is a very expensive product and it's going to be probably too expensive for most people to end up trying it. It is a bar."

Skin Obsessed Mary

33k subs

✓Yay

"I'm amazed at how quickly the skin calms down, how well it repairs, how resilient it stays over time. [...] This has become a holy grail must-have product. I am never without it."

Top Pick: anti-aging serum

Sincerely Miss Ash

195k subs

✓Yay

"This is next level, super innovative, backed by science, and one of the best anti-aging serums I have truly ever used. This is actually the next best thing to human growth factors."

Top Pick: anti-aging serum

All 2 takes from Sincerely Miss Ash

LUXURY SKINCARE THAT'S ACTUALLY WORTH THE MONEY - MY MOST USED HIGH-END PRODUCTS WITH REAL RESULTS

"This is next level, super innovative, backed by science, and one of the best anti-aging serums I have truly ever used. This is actually the next best thing to human growth factors."

BEST ANTI-AGING PRODUCTS FOR COLLAGEN STIMULATION & FIRMER SKIN | PRO- LEVEL RESULTS

"This serum is 10 out of 10. A little goes a long way. You don't need much of this. It spreads so nicely, and you want to work by per drop basically because one drop actually spreads quite far. [...] When you use this, you want to make sure that your skin is exfoliated, you don't have any dead skin or flaky skin because you just want this to penetrate into the skin nicely to do its thing right for anti-aging. I really have been enjoying that."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Frequently asked.

What is Calecim Professional Serum?

Is Calecim Professional Serum worth it?

Mostly yes. 2 of the 3 gurus who reviewed it give it their stamp of approval, for a Guru Score of 90%.

What is Calecim Professional Serum's Guru Score?

Calecim Professional Serum holds a Guru Score of 90%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.