Is Dr. Dennis Gross DermInfusions Fill + Repair Serum worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 68%.

Dr. Dennis Gross DermInfusions Fill + Repair Serum.

Q: What is Dr. Dennis Gross DermInfusions Fill + Repair Serum's Guru Score?

Dr. Dennis Gross DermInfusions Fill + Repair Serum holds a Guru Score of 68%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected.

Q: Who is Dr. Dennis Gross DermInfusions Fill + Repair Serum best for?

Dr. Dennis Gross DermInfusions Fill + Repair Serum is generally suited to dry skin and mature skin.

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Serums

About this product

A serum with peptides and exfoliating acids designed to target texture, fine lines, and hydration while supporting skin barrier repair.

Full ingredients

Water/Aqua/Eau, Glycerin, Niacinamide, Butylene Glycol, Ectoin, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Oligopeptide-2, Saccharide Isomerate, Camellia Sinensis (Green Tea) Leaf Extract, Camellia Sinensis (White Tea) Leaf Extract, Centella Asiatica Extract, Vitis Vinifera (Grape) Seed Extract, Sodium Carboxymethyl Beta-Glucan, Bakuchiol, Inonotus Obliquus (Mushroom) Extract, Tetrahydrocurcumin, Ceramide NP, Ceramide AP, Ceramide EOP, Phospholipids, Sphingolipids, Phytosphingosine, Colloidal Oatmeal, Bisabolol, Superoxide Dismutase, Terminalia Ferdinandiana (Kakadu Plum) Fruit Extract, Sodium PCA, Glutathione, Squalane, Caffeine, Panthenol, Butyrospermum Parkii (Shea) Butter, Aloe Barbadensis Leaf Juice

Guru Score

68%

Mixed

Early verdict · Few reviews so far

What the gurus are saying

Texture smooths visibly within days, credited to its peptide and exfoliating-acid blend. Opinion splits sharply on anti-aging impact: most gurus praise the formula for softening fine lines and boosting skin firmness, while skepticism emerges about whether it substantively addresses wrinkles despite the peptide content. All flag a mild floral fragrance that lingers slightly. Works for sensitive skin; patch-test before combining with tretinoin to check your tolerance.

Synthesized from 2 expert reviews · most recent take October 2025

What they liked

Improves texture and tone quickly
Firms and brightens skin
Works as a simplified routine staple

What they flagged

Better for younger skin than mature skin

Best for

Dry skin Mature skin

Type

SerumsDrops & dropper

Key actives

Retinoid Niacinamide Hyaluronic acidCeramidesPeptides Squalane

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Sephora → Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Sincerely Miss Ash

195k subs

~Yay

"This is one of the best serums I've ever used. It is one that will target multiple skin concerns. And if you truly wanted to limit down in your skincare routine and get rid of some of your serums, this could replace them because of the amount of key ingredients in here. So there's hyaluronic acid, there's peptides to help firm and stimulate collagen, there's niacinamide, there's some AHAs in here, there's beta glucan, centella asiatica. Honestly, the list truly goes on."

All 23 takes from Sincerely Miss Ash

5 NEXT LEVEL ANTI-AGING SERUMS THAT ACTUALLY FIRM SKIN AND MINIMIZE SIGNS OF AGING

"I just use two pumps, I put that all over my face and my neck. The only downfall with this is that there is fragrance, there is a floral scent that is quite mild, but if you can't do fragrance or you can't do floral then unfortunately you probably won't like this, but you are getting 30 mls of product. And I can't recommend this enough. This really is beneficial."

ALL-IN-ONE SERUMS THAT LITERALLY TARGET EVERYTHING - ANTI-AGING, BRIGHTENING, HYDRATION + MORE!

"This is the Dr. Dennis Gross DermInfusions Fill + Repair Serum. I've been using this on and off for a couple of years, and I will just use this sometimes with my moisturizer and sunscreen, and this performs so well, and it really is a serum that will target everything. It eliminates texture, giving the skin more of that softer, smoother feel. It brightens, softens fine lines. It helps to prevent, it hydrates, it repairs the skin. It brightens the skin. It does it all."

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"This is a serum that truly targets all skin concerns. It firms, it brightens, it improves texture and tone. It honestly helps to hydrate, repair the skin, soften fine lines and wrinkles. It's a great preventative serum as well. And it just gives this smoother, softer look and feel to your skin. It really rejuvenates the skin. You can use this twice a day or you can just use this once a day. I sometimes use this in the morning in replacement of vitamin C."

5 SKINCARE MUST-HAVES THAT ACTUALLY FIRM SKIN AND MINIMIZES SIGNS OF AGING

"I think this does a better job than using an exfoliating acid. When I use a lactic acid or something, sometimes it takes a while for me to see a difference in terms of texture, but with this one within 2 days that texture was completely wiped out. [...] It does firm like a dream. It is expensive, but in my opinion it really is worth the money. I just really love this product and this is honestly one of the best from Dr. Dennis Gross hands down."

13 BEST ANTI-AGING SKINCARE PRODUCTS 2024 | AGING BACKWARDS OVER 30 - THESE ACTUALLY WORK!

"All you would need is a cleanser, this product, a moisturizer, and sunscreen. That's truly all you would need as this is going to target texture, tone, it will help to improve fine lines and wrinkles, it hydrates, it repairs your skin barrier, and it does give a brighter complexion as well. It does it all. This is a product that you can use every day twice a day or just once a day, it just depends on what you want to do."

TOP 5 LUXE ANTI-AGING SERUMS THAT ACTUALLY DELIVER AMAZING RESULTS - SINCERELY MISS ASH

"This especially is amazing. If you wanted to simplify your skincare routine completely and just have a cleanser, a serum, a moisturizer, and a sunscreen you could easily do that with this because this is going to target texture, discoloration, fine lines, and wrinkles. It's going to help hydrate the skin, calm the skin barrier. It does it all, it truly does it all. When I first started using this within 2 to 3 days this wiped out the texture that I had on my chin."

MY MORNING ANTI-AGING SKINCARE ROUTINE | A.M. SUMMER SKINCARE ROUTINE | OVER 30

"I've been loving the Dr. Dennis Gross DermInfusions Fill + Repair Serum. This has peptides but it also has niacinamide, there's some AHAs in here. This is perfect if you have texture. This really helps to give your skin more of that smoother, brighter canvas, and I really really love this. I've been using this product in my morning routine, but I don't pair it up with vitamin C. I just use one or the other."

6 ANTI-AGING SKINCARE PRODUCTS I'M LOVING FOR 2023 | THESE WORK AND I AM SO IMPRESSED!

"This really is one of the best anti-aging serums that I have used so far in 2023. This serum literally does it all, it helps to exfoliate, it helps to brighten the skin, it helps to give that smooth soft canvas. It really helps to treat fine lines and wrinkles, to firm the skin, to hydrate, but also to help repair the skin barrier at the same time. If you're someone that can't use a vitamin C serum or a retinol or tretinoin, then perhaps you may want to try this."

IF I COULD ONLY PICK 1 PRODUCT FROM MY FAVORITE SKINCARE BRANDS | FYI...THIS WAS REALLY HARD!

"This really does a good job to give your skin that smooth soft canvas, and so when you have skin that is soft without any texture, of course your makeup goes on better, your tinted sunscreens are going to look nicer on your skin, everything is going to be more improved, and your skincare products in general are going to absorb better into your skin as well. I absolutely love this, I'm obsessed, I've been using this a lot lately."

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"This really has improved my skin, the texture and tone of my skin especially. I told you guys that I had texture on my chin when I first started using this and within a couple of days that texture was completely wiped out and it just keeps my skin super soft and it also has that brighter complexion as well. But with time and with continuous use this can really help with dark spots and fine lines as well."

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"And I just love the results that I see that I just always need to have this in my collection. I may not use this every time I finish up a new bottle. Like I might take a break from it and then maybe in a few months time I'll go back to it. Currently this is a part of my nighttime routine. It was for winter and spring. I am going to be switching things up a little bit now that I'm finished it, but I will consider using this again in the near future 100%."

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"This is really effective and it is worth the price tag. I know this is very expensive but the formulation is very impressive and there isn't anything like this on the market. I have not found a dupe to this yet. If you have a look at that ingredient list you're going to know what I mean. There are so many great ingredients in here to target fine lines and wrinkles, texture, tone, hydration, and to plump the skin while keeping everything nice and comfortable."

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"It plumps. It does it all. And this is exceptional. [...] Generally, I will do two pumps of this. [...] It spreads great. I've never experienced peeling with this. This doesn't leave your skin tacky or sticky, but you will have a little bit of a glow to your skin once it's all dried down. And this is one of the last serums that I use in my skincare routine because it does have a little bit of that milkiness to it. So, I might use a really nice hydrating serum beforehand and then this afterwards."

MY NIGHTTIME ANTI-AGING SKINCARE ROUTINE - SKINCARE OVER 30 (WINTER/SPRING SKINCARE ROUTINE)

"But it's also a product where if you really wanted to limit down on your skincare routine and honestly just use like one serum within your routine, this would be it. It has so many amazing anti-aging ingredients to target all skin concerns like discoloration, texture, tone, fine lines, and wrinkles. It helps to repair the skin. There's ceramides in here, there's peptides, there are so many wonderful ingredients in here and I can't get enough."

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"It's a great preventative serum. It's also very moisturizing and it helps to repair the skin as there are several ceramides in here. There are four types of peptides to help firm the skin. There are four types of hyaluronic acids to hydrate and plump the skin. There is superoxide dismutase which is an antioxidant. That ingredient is in here alongside other wonderful ingredients to improve texture and tone. Now the only thing with this is that there is fragrance and it's very mild."

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"This serum truly does it all. It helps with texture, tone, fine lines, and wrinkles. It's hydrating, it's repairing. [...] So if you were looking for a good anti-aging serum that targets multiple skin concerns, then I would go and check out that product."

PRODUCT'S I'VE USED UP | WOULD I REPURCHASE? BEAUTY EMPTIES 2023

"This product has been mentioned on my channel many times and I am obsessed with this. I use this a lot in my morning skincare routine so if I'm not using copper peptides or my vitamin C serum then I am using this. This is a serum that truly does it all. It helps to treat early signs of aging, it also helps to exfoliate to improve texture and tone. It really helps to hydrate and repair the skin at the same time. It really is one of a kind and the ingredient list is really impressive."

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"I have talked about this a few times on my channel and I feel like I could go through a bottle of this every month, that's how much I love it, that's how much I use it when it's opened. I will use this in the morning if I'm not using vitamin C and sometimes I will even use this at night time when I am not using my [tretinoin]. This is exceptional for so many skin concerns. It really helps to get rid of texture, it really helps to give that smooth brighter look to your skin."

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"The Dr. Dennis Gross DermInfusions Fill + Repair Serum, I am just absolutely obsessed with this. It has peptides and ceramides to strengthen and repair your skin barrier, and it has mandelic and glycolic acid in here to really help keep the skin nice and smooth. If you have any texture, this serum can really help to diminish your texture."

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"This is one of my go-to peptide serums, and there's a lot of other fabulous ingredients in here as well like niacinamide and there are some AHAs. This is one of those serums that will target multiple skin concerns like fine lines and wrinkles, dark spots, texture. It really helps to brighten up the skin. It really is a fabulous anti-aging product, and I love using this on a weekly basis, sometimes on an everyday basis as well. This one also has a fragrance to it."

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"That serum launched a few months ago and I am in love with it. It has really improved my skin. [...] Within three days of use I noticed a big difference with my skin. I had a little bit of texture on my chin that was completely wiped out. Since being consistent with it, the tone of my skin, the texture, it just looks so much more improved. It contains a lot of amazing anti-aging ingredients. It also hydrates, it exfoliates, and it's wonderful."

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"This gives my skin that super soft smooth look it gives my complexion that brighter look as well but with consistency this can help to soften fine lines and wrinkles to firm the skin and it really is exceptional. There is fragrance please keep that in mind there is a little bit of a floral scent to it it's very very mild but there is something there."

Nipun Kapur

412k subs

~Nay

"If your skin is normal, normal to combination, or oily, this is not a product that I recommend for you. If you use it consistently and after two weeks of consistent use, the only difference I felt on my skin was the skin felt smooth and hydrated. Fine lines and wrinkles with this one, and that is because the ingredient story is just going to give you hydration with a little bit of peptides, but it doesn't work on your fine lines and wrinkles."