A lightweight, fragrance-free vegan peptide serum with growth factors, designed to support firmness, texture and overall skin quality without human-derived growth factors.
Peptides and growth factors are the headline here, and several gurus call the blend good value for what you get. The split shows up around results and hydration, since some saw little change and very dry skin may find it not hydrating enough. Those with sensitive skin may want to see how well their skin tolerates it first, since the warmest praise depends on that.
Synthesized from 10 expert reviews · most recent take October 2026
"Again, a similar price point to Meditate, so it's that mid price. It's not super expensive, but you're getting great results. I'm going to give props to Dermatology as a brand because they spent an absolute fortune on tests around this product which were double-blind, peer-reviewed. So the best, like the highest quality test that you can do into a skincare product. And they found that it performed roughly the same as the Skin Medical one, which is like four hundred dollars and is human-derived."
All 4 takes from Mad About Skin
BEST GROWTH FACTOR SERUMS 2026 (For Every Budget)
"That needleless serum went viral around two years ago and everyone was singing its praises, genuinely an amazing peptide serum. They created an advanced version with growth factors added in, and if you look at the price point of their standard needleless serum versus the needleless with growth factors, there's very little price differential, so you're getting a whole lot more without actually paying much more. [...] That for me is why I tried it and I fell in love."
GROWTH FACTORS Exposed - Whats Going On With The Ordinary GF 15% Solution
"This is a phenomenal product that actually comes in at $67. That's around $60. This is one of the most affordable of those bio-engineer options and it's amazing. It's got five different forms of growth factor. So, it covers every base. They've done a lot of research into this product, put it through its testing, and the results really, I think, speak for themselves. People have been raving about this online. So, I bought it, I tried it, and I've been really, really impressed."
Global BESTSELLING SKINCARE 2026 - Rating Most Purchased Skincare
"It is a good product, it's a really good product, but there are a couple of growth factor serums I personally just prefer over this, it comes down to personal preference. When it was 50% off I bought a couple because it's really good, and at that price point who can argue. But I think the sales are slightly inflated because it had such a good saving attached to it, and I don't think it would have made this list were it not for that sale."
MAJOR GROWTH FACTOR UPDATE - The Ordinary GF 15% Solution (2 Years Later)
"Again, a similar price point to Meditate, so it's that mid price. It's not super expensive, but you're getting great results. I'm going to give props to Dermatology as a brand because they spent an absolute fortune on tests around this product which were double-blind, peer-reviewed. So the best, like the highest quality test that you can do into a skincare product. And they found that it performed roughly the same as the Skin Medical one, which is like four hundred dollars and is human-derived."
"I have finished Dermaty's Needleless Growth Factor Serum and I really really liked it and for what you're getting I think the price is so hard to argue with. The only reason that I haven't repurchased it is geography. Like I don't love paying import charges when I already own other growth factors. So, I suppose it's more editing than rejection. Like, if they sold it here, I probably would repurchase."
"It's also clinically proven to outperform the leading human growth factor serum that retails for $295. By far, this is the cheapest option on the list. The key ingredients here are the five times biogrowth factor complex, this versa chirata extract and the palmatyl trapeptide. I am currently using this one and I like it a lot."
Top Pick: growth factor serum
All 3 takes from Dr. Aleksandra Brown
Growth Factors in Skincare: Are They Worth the Hype? A Dermatologist Explains
"It's also clinically proven to outperform the leading human growth factor serum that retails for $295. By far, this is the cheapest option on the list. The key ingredients here are the five times biogrowth factor complex, this versa chirata extract and the palmatyl trapeptide. I am currently using this one and I like it a lot."
Top Black Friday Skincare Sales 2025, According to a Dermatologist
"I've used it morning, evening, and honestly, it works great morning and evening. I used it last night and this morning. I put it in the morning on top of my vitamin C. It's vegan. It's biotech powered growth factor serum designed to support firmness, texture, and overall skin quality without using any human derived growth factors. Some people are really particular on that, so this is completely vegan."
How a Dermatologist Transitions Her Skincare for Fall | Dr. Aleksandra Brown’s AM & PM Routine
"This dermatology serum is relatively new to me. I really like the way it feels. I love it goes how it goes on. I have used it sometimes just in the evenings. I have also used it a couple times a day."
"This is the dermatology Needleless Growth Factor Serum. It's a really nice serum from dermatology and it has multiple different peptides that act as growth factors in the skin. And that is able to stimulate your skin cells, fibroblast growth factor, platelet derived growth factors that can stimulate your collagen and elastin to build. It can speed up your skin cell turnover."
All 3 takes from Doctorly
PART 2: 2025 BEST BLACK FRIDAY CYBER MONDAY SKINCARE AND DEVICE DEALS LIVE
"This is the dermatology Needleless Growth Factor Serum. It's a really nice serum from dermatology and it has multiple different peptides that act as growth factors in the skin. And that is able to stimulate your skin cells, fibroblast growth factor, platelet derived growth factors that can stimulate your collagen and elastin to build. It can speed up your skin cell turnover."
Ultimate Skincare Routine for 40s, 50s, 60s, and Beyond!
"The Dermatology Needleless Growth Factor Serum also has additional benefits. I love that, been using that a long time on and off. It's outstanding."
ARE GROWTH FACTORS WORTH THE HYPE? Doctorly Explores
"So when they're evaluating this person over the course of the study, they just look purely at the outcomes, and then someone else, once all the data is in, attributes it to which serum they were actually using. It showed that it was superior in a few of the endpoints and statistically significant for that, which is a really good sign. It gives me confidence to use it. I've been using it pretty consistently and I like it quite a bit."
"This contains hyaluronic acid, ceramides, and niacinamide, but this also takes it a couple of steps further. This contains a couple of peptides and it also has a copper peptide in it. This is more spendy than most of the other things, at about $70. This is a really lightweight serum. I really love how it feels going on the skin, I love the finish on it, and it's just a great serum that is packed with really great anti-aging ingredients."
BIGGEST Black Friday BEAUTY DISCOUNTS! 25% - 58% OFF!
"The last product of DRMTLGY that I really, really love is their needleless serum. This is a great serum that is so packed with so many great ingredients. This contains niacinamide, hyaluronic acid, a copper peptide material, it contains ceramides. It's normally $69 for an ounce, it's now $48.30 with your 30% off, and it also comes in a 2 ounce size."
Faves + Fails! BEST & Worst NEW Makeup, Skincare & Fashion! + The BEST Dupe of a Top Seller!!
"Another product I talked about in my skincare video was the DRMTLGY Needleless Growth Factor Serum. This is a really great multitasking serum that I usually use in the summer when it's hot and humid and I don't feel like putting on a lot of heavy layers of moisturizer, and this has everything that is usually in two or three of my moisturizers all combined into one bottle, which is awesome. So it's got ceramides, it's got niacinamide, it's got a couple of peptides in it."
What You CAN Use With COPPER PEPTIDES!
"This is the one copper peptide that I have ever used. It's not blue, it's a clear serum. Even though DRMTLGY says that their Needleless Serum can be used with anything, anywhere in your skincare routine, if you look at their product FAQs there's one about vitamin C and the Needleless Serum, and they say the one vitamin C serum that should be used at a separate time than the Needleless Serum is ascorbic acid, which is found in their Vitamin C E and F."
Best of 2022 ~ Skincare + Anti Aging!
"The needle is serum is more of a serum texture and it has all the same ingredients as the CeraVe it has ceramides and niacinamide and you know hyaluronic acid and glycerin and all that good stuff it also contains a copper peptide."
Faves + Fails! New HG Concealer + HG Sunscreen! May 2022
"It's kind of like a combination of my CeraVe PM lotion and my Olay Night Recovery cream all packed into one little serum. [...] I've looked into the research on vitamin C reacting with copper, and [...] the kind of copper used in this is [...] copper peptide, which is stabilized and bound together as [...] an amino acid, so [...] I don't think you need to worry about it. [...] I've really been enjoying using this and I do use it in the morning."
Top Skincare Products for Spring & Summer 2022! Lighten Up for Spring!
"This is a beautiful serum and the ingredients are so great. This is like a little powerhouse of a serum. [...] It's super clear, it's a super lightweight liquid. It rubs in so beautifully, it doesn't leave any heaviness or any tack on the skin. It's got ceramides, it's got niacinamide, glycerin, it's got three different peptides in it, and it's got hyaluronic acid and it's all packed in this one nice little bottle."
"That is one product that just doesn't work for me. [...] I personally just didn't see that much of a difference in my skin when I used it. And also, it just wasn't quite hydrating enough for me."
All 2 takes from Beyond50Skin
DRMTLGY Skincare: Best Anti-Aging Skincare for Mature Skin Over 50 (Black Friday Deals!)
"That is one product that just doesn't work for me. [...] I personally just didn't see that much of a difference in my skin when I used it. And also, it just wasn't quite hydrating enough for me."
Best Anti-Aging Skincare for Over 50 | Ranking DRMTLGY's Top 10 Best Sellers
"I've tried the Needleless Growth Factor Serum and I just didn't find the wild factor that so many of you love. [...] It has niacinamide, it has copper peptides, it has ceramides, and it has hyaluronic acid. For a one-and-one serum, for many of you this could be the answer, but I have very very dry skin and this isn't quite hydrating enough. I also treat different skincare concerns in my treatment step in the morning than just hydration."
"It has this anti-redness property, plus it's good for skin yellowing. So if you tolerate it, it's really quite a good ingredient. [...] If you were gifted it or you bought the DRMTLGY one, I'd say thumbs up, use it. It's good if you tolerate it. I had no problem with it."
"Their needleless serum, needleless serum, not needless serum, is also great and full of peptides. [...] It's worth looking at."
All 3 takes from No BS Beauty
Which Peptides Do You Need in Your Skincare for Anti-Aging? Top Peptides for Wrinkles
"Their needleless serum, needleless serum, not needless serum, is also great and full of peptides. [...] It's worth looking at."
Best Serums with Ceramides for Smooth, Soft Skin - My Favorite Hydrating Serums
"So in here we got ceramides, peptides, panthenol, vitamin E."
DRMTLGY Brand Sale - More Affordable Than Most Drug Store Brands! Product Faves
"This one's really nice, it's just a water-based serum. It's got P extract which is really good for your skin, it's got the matrixyl 3000 peptide anti-aging duo, it's got ceramides, it's also got panthenol. So this one's really nice, it's a really nice water-based serum you can pretty much easily fit it into most routines without any issue. Some really nice anti-aging ingredients in there."
"I do think this is a good peptide serum. I like that it's nonirritating and fragrance free, it has some ceramides and panthenol in it, and it's got a nice lightweight texture, I think everybody will like this one. I received it in PR, but in all truth I don't think I'll buy it again because I like the Ordinary's multi-peptide serum just a little more, and [...] if the Ordinary is working well for you, why change things."
"I also really like the Dermatology Needle-less Growth Factor Serum."
Sponsored
All 16 takes from Sincerely Miss Ash
6 ULTIMATE TRETINOIN PAIRINGS TO MAXIMIZE RESULTS FOR SIGNS OF AGING AND SKIN REPAIR
"This is way better than the original needleless serum in my opinion because I love the growth factors in here. And this really does firm the skin and I find this gives a glow to the skin as well. And I do have a 20% off discount code with dermatology also. So if I'm not using the Allies of Skin, sometimes I will switch it up and use this one instead. And sometimes I will use this in my morning routine as well, as this can also be used twice a day."
HONEST BEAUTY EMPTIES | SKINCARE & HAIRCARE PRODUCTS I'VE USED UP + WILL I REPURCHASE?
"This has a milkiness to it, whereas the original needleless serum is more like water, but the original one does not have growth factors in it. So if you love growth factors and peptides, this formulation really is worth looking into. But this on its own is 10 out of 10. If you didn't want to pair this up with anything, then just pair this up with a moisturizer and a sunscreen if it's in your morning routine and away you go."
BEST ANTI-AGING PRODUCTS FOR COLLAGEN STIMULATION & FIRMER SKIN | PRO- LEVEL RESULTS
"This is really nice and it's also very lightweight on the skin. There's no fragrance. Great for all skin types and this is 10 out of 10."
12 DRMTLGY BEST SELLERS || I HAVE TRIED EVERY ONE.. ARE THEY WORTH THE HYPE? SINCERELY MISS ASH
"I do like to use this in the morning sometimes and sometimes I do like to use it at night time paired up with [tretinoin] or with a [retinaldehyde]. I do like to use this with other things of course you don't have to, you can just use this on its own paired up with a moisturizer, but it really is a lovely anti-aging serum for every day. I'm going to give this a 9 out of 10."
"This has to be Dermatologist's best seller. You see this everywhere. There are so many success stories with this, and this is a serum that I've been using for several years. I just always need to have it in my collection because I feel like it has a wonderful formula that actually performs. You can use this long term, and use this at least once a day, and this really does help to firm the skin and soften fine lines and wrinkles. You can use this twice a day if you want to."
DRMTLGY BIGGEST BLACK FRIDAY SALE 2025 | TOP 11 ANTI-AGING PRODUCTS THAT DELIVER REAL RESULTS!
"I am very impressed with this formulation. [...] This contains five bioengineered growth factors. Growth factors help to stimulate collagen and it helps with fine lines and wrinkles. It firms the skin, but it also has the ability to heal your skin. So if you have sensitive skin, you have a compromised skin barrier, then this can be a great product to use to keep your skin healthy and repaired. But it's also very hydrating and I find this serum to be quite plumping as well."
DRMTLGY BLACK FRIDAY SALE 2024 | MUST HAVE ANTI-AGING PRODUCTS THAT ACTUALLY DELIVER RESULTS!
"The DRMTLGY Needleless Growth Factor Serum is probably one of Dermatology's most popular products. It's a great anti-aging serum to soften fine lines and wrinkles, to help firm the skin, to give fullness, and it's an amazing hydrating serum as well. This serum contains several types of ceramides which can help to repair and strengthen your skin barrier, there are peptides in here, there's niacinamide, hyaluronic acid, provitamin B5, and there is a copper ingredient in here as well."
4 TOP PERFORMING GROWTH FACTOR SERUMS FOR ANTI-AGING, COLLAGEN BANKING, SKIN HEALTH AND MORE!
"I am so impressed with this formulation. I had a feeling I was going to like it because I love the original needleless serum, but this is a little different, more advanced. The texture is very milky and has a thickness to it, way more hydrating and plumping than the original needleless serum. It truly gives the most incredible healthy glow to your skin, but without your skin looking greasy and shiny."
BEAUTY PRODUCT'S I'VE USED UP || BEAUTY EMPTIES 2024
"Although I really love this, I'm going to pass for right now because I like the results that I see from a traditional copper peptide serum. But I would consider using this again. It really is a lovely serum, super hydrating, it's great to tackle signs of aging and of course to firm the skin as well."
THE TRUTH ABOUT COLLAGEN BANKING | WHY IT'S THE NEW ANTI-AGING TREND - BEST ANTI-AGING SKINCARE 2025
"This is very hydrating, it just feels incredible on the skin, and it gives this youthful plump to the skin. I haven't been using this for too long, but I've been using it every day, twice a day, since I received it, and I am really impressed with the texture, the formulation, how it layers with my other skincare products. It also sits great underneath makeup. [...] I was using this all summer long, both morning and evening, and I can't say anything negative about it."
BEAUTY EMPTIES 2025 || SKINCARE AND HAIRCARE PRODUCT'S I'VE USED UP - PROJECT PAN
"I do have a backup in my linen closet. I actually have the large size, I believe it's 60 mils. This is a 30 mil size, so depending on what size you want to go with, you've got two options here, but if you're someone that is going to use it a lot, I would say go with the larger size because it's just going to last a lot longer, especially if you're using this twice a day."
6 ANTI-AGING PRODUCTS FROM DRMTLGY THAT I CAN'T STOP USING | THESE REALLY DO WORK FOR SIGNS OF AGING
"This really is a lovely serum for signs of aging to firm the skin and also to hydrate the skin. This is a product that you can use every day twice a day and this is basically your peptide serum. It has a few different peptides but there's also a copper peptide complex in here which is another reason why I love this one so much because I am the biggest fan of copper peptides."
🔥BEST BLACK FRIDAY/CYBER MONDAY SKINCARE SALES 2025! MUST-HAVE ANTI-AGING PRODUCTS & MAJOR DISCOUNTS
"This is the new Needleless Growth Factor Serum, and I love this so much. It's a little similar to the original needleless serum, but this one has growth factors. I also really like the texture of this. It's more of a thicker, milky, creamy type of texture over the original needleless that's more thin and watery. This one gives more hydration to the skin. It gives a little plump to the skin as well."
21 BEAUTY PRODUCTS I'VE USED UP | BEAUTY EMPTIES 2026 - SKINCARE, MAKEUP & HAIRCARE - PROJECT PAN
"This one is a little more moisturizing in my opinion, so if you're on the drier side or have tight skin, you might like this one more. [...] It doesn't interfere with skincare, I've never experienced peeling with it, and I pair it with [tretinoin] and copper peptides too. This is just as effective as Allies of Skin. I [...] have a 20% off discount code, and I have a backup so I don't need to purchase one right now."
WHY YOUR ANTI-AGING SKINCARE ISN'T WORKING (The Truth About Skin Barrier Health + My Top Picks)
"If I'm not using the Allies of Skin one, then I really like the dermatology one, the Needleless Growth Factor Serum. This one contains five growth factors. The texture of this is a little bit thicker, it's still milky like the Allies of Skin one but a little bit on the thicker side. So if you are somebody that likes that heavier serum, something that's a little bit more moisturizing on the skin, then you might like this one a little bit more."
8 POWERFUL SKINCARE PAIRINGS THAT CAN ACTUALLY IMPROVE SIGNS OF AGING FASTER!
"I also really like the Dermatology Needle-less Growth Factor Serum."
What the evidence says.
Independent of what the gurus think, this is what
the published research supports about the main active ingredients here.
Frequently asked.
What is DRMTLGY Needleless Growth Factor Serum?
A lightweight, fragrance-free vegan peptide serum with growth factors, designed to support firmness, texture and overall skin quality without human-derived growth factors.
Is DRMTLGY Needleless Growth Factor Serum worth it?
The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.
What is DRMTLGY Needleless Growth Factor Serum's Guru Score?
DRMTLGY Needleless Growth Factor Serum holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.
Who is DRMTLGY Needleless Growth Factor Serum best for?
DRMTLGY Needleless Growth Factor Serum is generally suited to mature skin.
Cheaper alternatives the gurus rate.
Lower-priced serums the gurus still rate highly, versus this mid-range pick.
More from
DRMTLGY
→
