Is DRMTLGY Peptide Night Cream worth it?

Mostly yes. 4 of the 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 77%.

What is DRMTLGY Peptide Night Cream's Guru Score?

DRMTLGY Peptide Night Cream holds a Guru Score of 77%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 expert reviewers we have collected.

DRMTLGY

DRMTLGY Peptide Night Cream.

Save to Pinterest

Moisturizers

About this product

A fragrance-free, peptide-enriched night cream from DRMTLGY, designed to moisturize the skin with ingredients such as shea butter, ceramides and vitamin E.

Full ingredients

Water/Aqua/Eau, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii (Shea) Butter, Caprylic/Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Tridecane, Allantoin, Tocopherol (Vitamin E), Glycol Distearate, Potassium Cetyl Phosphate, Butylene Glycol, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polysorbate 20, Dextran, Magnesium Chloride, Phenoxyethanol, Disodium EDTA, Sodium Hydroxide

Guru Score

77%

Yay

5 experts · Moderate agreement

What the gurus are saying

The whipped, marshmallowy texture is the detail that keeps coming up, and it rubs in easily while feeling rich without turning heavy. Dry and normal skin seem to be the best fit, and some reviewers pair it with retinol at night, while combination or oilier skin may find it too much in summer. The one mixed take liked it but found the experience of use less memorable than another product it tried.

Synthesized from 5 expert reviews · most recent take July 2026

What they liked

Rich moisturization without a heavy feel
Works as both day and night cream
Fragrance-free and supports barrier repair

What they flagged

Texture didn't stand out to some
Too heavy for oily or combination skin in summer

Type

MoisturizersCream

Key actives

Vitamin ECeramidesPeptides

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Ulta → Amazon → Google →

Opens a store search. We may earn from these links.

Scan it in the shopFree iPhone app. Scores in the aisle.

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

AliceintheRabbitHole

59k subs

✓Mixed

"I finally finished the Dermatology Peptide Night Cream. I know a lot of people really love this brand, and they were kind enough to send me products, but I didn't feel as wowed by this as I thought I would. Don't get me wrong, I like it, I finished it, but there wasn't a lot that stood out to me. The ingredients look great, but the experience of use just didn't stand out the way a product like the Experiment did."

No BS Beauty

89k subs

✓Yay

"Next up is the DRMTLGY Peptide Night Cream, which is about 46 bucks. It's a peptide enriched cream. It's fragrance free, great for sensitive skin. It's great for barrier repair as well. It's really nice. DRMTLGY has a lot of nice stuff."

All 13 takes from No BS Beauty

Dozens of Empties - Last of the Year Skincare & Beauty Products I've Finished Up

"Dermatology Peptide Night Cream, very nice product, love it. I already have a backup of this one as well."

The Best Hydrating Moisturizers for Winter ❄❄ Cold, Dry Weather Face Creams to Prevent Dryness!

"Last but not least, the DRMTLGY Peptide Night Cream. It's really full of good ingredients. We've got shea butter, we've got peptides, we've got ceramides, we've got vitamin E, we've got allantoin, we've got cholesterol. It's really nice. It comes with the little plastic thing, so I just kind of do that thinking it protects it, but I'm sure it probably doesn't make that much of a difference. Pretty thick product and wonderful."

Which Peptides Do You Need in Your Skincare for Anti-Aging? Top Peptides for Wrinkles

Favorite Peptides, Peach & Lily Softening Toner, Beauty of Joseon SPF, Volufiline- LIVESTREAM 2-14

"Next up is the DRMTLGY Peptide Night Cream, which is 34 bucks. This one also has ceramides, shea butter, vitamin E, and allantoin."

My Favorite Peptides - Peptides You Want in Your Skincare Routine & Product Favorites

"The DRMTLGY Peptide Night Cream is 34 bucks. It also contains [...] going camid, shea butter, vitamin E, and allantoin."

My Ultimate List of the Top Ten Moisturizers of All Time & I've Tried Hundreds of Moisturizers

"Last but not least, the DRMTLGY Peptide Night Cream, 2.1 ounces for 46 bucks, although they have sales and discounts on their website all the time. Fragrance-free, alcohol-free, cruelty-free, vegan. Its main components: glycerin, shea butter. It's also got ceramides, it's got the Matrixyl 3000 peptide duo, it's got the Syn-Ake peptide, which can help skin produce sodium hyaluronate according to research, and then a lantern."

Best Peptide Moisturizers for Anti-Aging & Firming Skin - Peptide Facial Creams I Love!

"The DRMTLGY Peptide Night Cream is 2 oz for 32 bucks and it contains the Matrixyl 3000 peptide, it contains the Syn-Coll peptide, and then it contains the Syn-Ake peptide. It also contains shea butter, ceramides, and vitamin E. It's really nice, and you don't have to just use it during your evening routine, you can use it morning or whenever."

Top 50 Best Skincare Products of 2023 💖✔ Part One - My Favorite Skincare Products of the Year!

"I love the DRMTLGY Peptide Night Cream. It's really wonderful, fragrance free. You don't just have to use it in your evening routine, I use this in my daytime routine as well. I think it's a good alternative to the Drunk Elephant Protein, which has gotten really expensive. The ingredient highlights: shea butter, five different types of peptides, different ceramides, vitamin E. It's fragrance free, it's wonderful. The bottle is a little bit bigger, it's 2.1 ounces compared to the Protein at 1.7."

Best Ingredients to Build an Anti-Aging Skincare Routine - Ingredients to Boost Collagen in Skin

"The DRMTLGY Peptide Night Cream has got the good peptides in there. Really nice, moisturizing cream, not terribly expensive, it's really nice."

9 Moisturizers Better Than the Olay Collagen Peptide 24 Hydrating Face Cream - Cruelty Free!

"It also contains several ceramides, which make it really nice for skin. It's fragrance free, cruelty free, and vegan. I'll link to it. Dermatology, they have some really nice stuff, if you haven't tried anything from them check them out, because they have a lot of products that are dupes for a lot more expensive products, so I think they're well worth checking out for that reason alone."

Best Thick Moisturizers for Dry Skin & Winter Weather - My Favorite Ultra Hydrating Face Creams!

"Next up the DRMTLGY Peptide Night Cream, which is really nice. It's got peptides in it. What else, it's got some silicones, it's got ceramide, it's got the urea in there, it's got allantoin, it's got vitamin E. [...] I would almost say this is thicker than the last one, man, it's hard to kind of rationalize all the thicknesses of them. [...] But very nice, it's great for anti-aging. They do say it's a night cream, but honestly I use this one in my daytime if I'm not using an ascorbic acid serum."

Favorite Peptide Moisturizers 😁 Best Anti-Aging Face Creams Featuring Peptides - Fragrance Free!

"The DRMTLGY Peptide Night Cream is a little bit more expensive than the last one, however I want to remind everyone this one is just over 2 oz, so it's like 15% more, it's a little bit more pricey. [...] It's 46 bucks. So in here we've got shea butter, we've got several different ceramides, we've got five different peptides, and we've got vitamin E. Well worth checking out."

DRMTLGY Brand Sale - More Affordable Than Most Drug Store Brands! Product Faves

"It's really nice, sometimes they use it during the daytime as well. It contains five different peptides, it also contains three different ceramides. It's a really nice fragrance-free skincare cream and you can certainly fit it into your evening routine or your morning routine. It's really nice, and it's 32 bucks, and it's 2.1 ounces, so it's a little bit larger than the average moisturizer. I'm getting low on this one, so I'll definitely be stocking up on this one during the sale."

Dr. Sam Ellis

898k subs

✓Yay

"This is a mid-weight cream that glides on the skin so smoothly and rubs in so easily. I actually really like to use it as a moisturizer during the day because I feel like it layers so well under sunscreen on a day that I'm feeling particularly dry, and then I save even thicker richer products for nighttime."

All 2 takes from Dr. Sam Ellis

My Nighttime Skincare Routine for Clogged Pores & Melasma (Pregnancy Approved!) | Dr. Sam Ellis

"The moisturizer I have been loving lately is the Dermatology Peptide Night Cream. This is sort of a thick [...] whipped sort of like a marshmallowy texture that rubs in really well and it just feels delicious on the skin. [...] It is very rich but still doesn't feel super thick or heavy, and that's the thing I've loved about it the most. You get the moisturization that you want out of a thick night cream without that thick night cream feel."

Dermatologist's Favorite Skincare Products of 2022: Cleansers, Moisturizers, Sunscreens, & More!

Beyond50Skin

32k subs

✓Yay

"The Peptide Night Cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."

Sponsored

All 10 takes from Beyond50Skin

BEST DRMTLGY FOR MATURE SKIN: My "Sleeper" Pick & The Concealer Fix!

DRMTLGY Skincare: Best Anti-Aging Skincare for Mature Skin Over 50 (Black Friday Deals!)

"This was the first product I ever tried from dermatology, the Peptide Night Cream. It is a beautiful mediumweight moisturizer. Perfect for normal to dry skin."

DRMTLGY BLACK FRIDAY/CYBER MONDAY: Best New Vitamin A Eye Cream + Top Picks For Over 50 Mature Skin

"You can use this day or night. In the winter and fall months I need something this hydrating for my daytime routine. It's kind of a fluffy, sort of creamy formula, soaks right into the skin, doesn't leave a greasy residue. I think it's great for maybe not very oily skin but anywhere from dry skin to slightly oily or normal skin you're going to really enjoy DRMTLGY Peptide Night Cream."

Should You Change Your FALL & WINTER ANTI-AGING SKINCARE ROUTINE?

"My budget pick for moisturizer is the DRMTLGY Peptide Night Cream. Great budget pick, gets the job done, super nourishing. You can use it as a day moisturizer or a night moisturizer."

Best Skincare For Mature, Over 50 Skin! (New DRMTLGY Launches & Favorites)

"Of course my Holy Grail Peptide Night Cream, the DRMTLGY Peptide Night Cream now comes in a huge tub. I certainly hope they do something with the lettering, mine always smears off. You guys asked and apparently they decided to deliver on a jumbo tub of the Peptide Night Cream, so it will save you a little bit and you won't have to keep repurchasing and wasting plastic. I think that is an awesome move on their part."

Skincare HACKS FOR MATURE SKIN! (DRMTLGY Fails, Faves and Tips!)

"I love their Peptide Night Cream. I've [...] loved it for years and years [...] and it's one of moisturizer that I have used for years and years. I love the texture of the Peptide Night Cream, and it's nice to have it in a jumbo size for a little bit of savings."

SKINCARE Fails & Faves for Mature Over 50 Skin (DRMTLGY 30% BlackFriday/Cyber Monday Sale)

"The Peptide Night Cream is amazing. I love this. It now comes in a jumbo. I use it summer, I use it winter, I use it morning, I use it evening. If you have dry skin, you have mature skin, you're going to love this. It's just a nice fluffy formula, one of my absolute all-time favorite moisturizers."

Best Anti-Aging Skincare for Over 50 | Ranking DRMTLGY's Top 10 Best Sellers

"I have purchased this countless number of times. I love it. I've used it for over 3 years. I recommend it all the time. I even recommend it for normal to oily skin types using a thin layer in the evening. It can be your night cream. You can also use it to buffer your retinoid products or sandwich your retinoid products with this. It can help protect so that you don't get that irritating red and flakiness. This is one of the best moisturizers I think that is out there on the market."

Beauty Empties Fails & Faves | Plus Skincare I Love for Hyperpigmentation & Facial Inflammation

"This is a little bit [...] thicker in consistency, but a really nice moisturizer that I have used up and enjoyed."

Build A BEGINNER ANTI-AGING AM & PM SKINCARE Routine for Mature Over 50 Skin

"Another great find is the DRMTLGY Peptide Night Cream. Honestly, it's a midweight moisturizer that can be used for morning and night."

Sincerely Miss Ash

195k subs

✓Yay

"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine."