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Drunk Elephant Protini Polypeptide Cream.

Drunk Elephant Protini Polypeptide Cream
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Moisturizers
About this product

A lightweight gel-cream moisturizer combining multiple peptides, amino acids, and growth factors designed to hydrate, firm skin, and improve texture.

Full ingredients

Water/​Aqua/​Eau, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/​Folic Acid Ferment Extract, Nymphaea Alba Root Extract, SH-Oligopeptide-1, SH-Oligopeptide-2, SH-Polypeptide-1, SH-Polypeptide-9, SH-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/​Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA

More from Drunk Elephant 32 products · Guru Score 67% →

Guru Score

65%

Mixed

18 experts · Strong agreement

What the gurus are saying

This cream earns consistent praise for its lightweight gel texture that absorbs quickly and works across skin types, with dermatologists noting it contains a substantial peptide complex including copper peptides that visibly improve fine lines and firmness. The split centers on value and texture: several gurus love it as a versatile two-in-one that layers beautifully under vitamin C or retinoids, while others find the price steep for what it delivers, and a few note that without silicones it can feel slow to absorb and buff into skin. One concern worth knowing: a batch tested positive for common skin microorganisms like yeast, which most people shed without issue but those with compromised skin barriers may want to patch-test first.
Synthesized from 18 expert reviews · most recent take September 2026

What they liked

  • Lightweight gel cream texture absorbs quickly
  • Works layered with vitamin C and sunscreen
  • Peptide blend clinically supported

What they flagged

  • Foams or froths when layered with vitamin C
  • Slow to blend in without silicones
  • Pricey for the peptide concentration

Best for

Type

MoisturizersCream

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
~Yay
"I also like that this is lightweight enough that you could easily use it during the day, layering it [...] with vitamin C and sunscreen, or you could use it in your nighttime routine after your retinoid. My verdict here is stay. This is a really good two-for-one product, and although it is $72, if you look at the cost of a peptide serum and a moisturizer separately, you might end up at that cost in two separate steps."
~Yay
"I love Drunk Elephant products. I think they're very effective and straightforward with clean ingredients, and this is one of my favorite more gel-like moisturizers."
~Mixed
"I've had a little bit of issues with the Protini foaming up before, especially in a routine with vitamin C, but I didn't have any issues with that today. It applied really nicely, it doesn't look too greasy, it looks like a nice natural finish, and there's no fragrance in it, and it's got some nice anti-aging peptides. The Protini played great over my vitamin C serum, I don't know why I had issues with it foaming up before, but it seems to be a winner today."
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"I've had a [...] problem with the Drunk Elephant Protini, which is why I stopped really using it. It foams up over vitamin C serum."
I'm from Licorice Calming Cream Review, How to Use, Dupes & Alternatives
"I used to use Drunk Elephant Protini for I don't know for a couple years there I used that a lot. I don't know something in it changed and anytime I would apply it over vitamin C or even exfoliant it would foam up and it would take minutes for it to defoam so that instantly became a no for the daytime routine."
A Lifetime of Moisturizer Testing 💧💦 What Actually Held Up & My Most Purchased Face Creams
"I really loved it. Something in it changed or something about my skin chemistry changed. I don't know what it is, but I don't love it anymore. Usually when I apply it, it froths up. [...] It got very expensive and for some reason something that just started to not work as well and I didn't like the foaminess and it became a high maintenance product."
Expensive Luxe Skincare Product Dupes & Affordable Alternatives 💲🏆😍 Frugal Friday
"It's expensive. It's a great moisturizer but a lot of us are kind of over some of the brand and some of the things the brand has done."
Beginners Guide to pH - Why pH Matters in Your Skincare & How it Impacts Your Skin
"So here is the Protini. [...] I would say the pH of this is probably around 5.5. [...] Face serums typically fall between 4 to 6, and retinol products between 4 and 6.6. The real kicker is that some skin types can be sensitive to products with a pH that is too low as well as too high."
My Ultimate List of the Top Ten Moisturizers of All Time & I've Tried Hundreds of Moisturizers
"It's got a nice gel texture. It's still a great moisturizer. A lot of people use it and love it. I kind of switched from using it, but out of all of my moisturizers that I love, this is one of the ones I've repurchased the most. I probably wouldn't repurchase it at this point, but it's still a great one."
K-Beauty Dupes for Sephora's Most Expensive Products - Affordable Alternatives
"I've probably done two videos on my initial dupes and then my second run of dupes on it and that's the Drunk Elephant Protini Polypeptide Cream. I've spent my share of hard earned money on it and there's so many good dupes for it."
July Skincare & Beauty Product Empties 🙌 What I've Finished This Month!
"I don't know what happened to it, but anytime I apply it to my skin it foamed and frothed up and it was really unpleasant. I finally finished it on my décolletage area. I mean, it just foamed. I have one more jar that I got for Christmas, I think a couple of Christmases ago, and I'm having the same thing happening. It's foaming up. I don't know what the deal is. For a while I thought maybe this was just a bad batch, but the lot numbers on these are totally different."
Amazing August Skincare & Beauty Product Empties - What I've Finished This Month!
"The Drunk Elephant Protini, man, it used to go through like one of these jars like a month or something like that, it was insanity, and now I go through one of these a year. So times have changed. That's okay. It's expensive."
Ask Me Anything Part One - Age, College, Product Recommendations
"The Drunk Elephant Protini is a nice one"
Budget-Friendly Alternatives To Expensive Skincare Products - The Ordinary Dupes - Frugal Friday
"Every time I apply this it foams up, unless I apply it on dry skin with nothing else on it, it foams up, and even then it foams up. I don't know something changed or I have no idea, but it foams every time, and I used to love this stuff, man. I would go through it so fast, and now I'm still working on the same jar for like [...] a year or two years. I don't know, it just foams up."
🆕 Drunk Elephant Affordable Dupes for Protini Cream, Lala Moisturizer, & BrightFacial Mask
"It feels nice. The real deal [...] has no chemical smell which is nice. Both [...] feel very similar in terms of texture. [...] The first three ingredients [...] are the same: water, glycerin, and then diethyl carbonate. [...] Instead of using the marula oil that Drunk Elephant uses, the dupe product used macadamia oil instead, which I found interesting."
7 Anti-Aging Strategies to Enhance Youthful Skin & Boost Collagen Production to Fight Wrinkles
"Very similar to the Drunk Elephant Protini in terms of ingredients."
Then vs Now - What Cult Skincare Products Stand the Test of Time
"So in my opinion, this one's not relevant anymore. There's really nice dupes and alternatives that you don't need to spend that much for. One of them being the Neogen Dermatology High RX Exosome Cream, which I think is 19 bucks right now. It's got a lot of the same great ingredients, anti-aging ingredients, resveratrol, it's lovely. This has no scent, and this one doesn't foam every time I apply it. And you're saving around 50 bucks."
Drunk Elephant Moisturizer Versus - Comparison and Dupes For Bora Barrier, Protini, and Lala Creams
"It's got a wonderful texture to it. It's really nice because I can mix this in with my bronzing drops no problem and it soaks in pretty nicely. It doesn't look too greasy or shiny. Really versatile product overall. I think that's what people end up liking this because it's so versatile. You can use it morning, evening. It's great for oily skin, dry skin, aging skin, youthful skin, whatever. For acne prone skin it's probably their most friendly product."
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"I love it, it's probably out of all these one I've repurchased the most. However, I don't know something changed in it because almost anytime I apply this now it foams up. [...] It's a good moisturizer, it works well for so many people. It's expensive, it's 69 bucks. Something changed or something I changed or maybe something in my skin changed, but almost anytime I apply this now it froths up on me. I don't know, but one of my best friends just bought it and loves it, doesn't have that issue."
K- Beauty Dupes for My Favorite Pricey Skincare Products
"I don't lately the Protini, it just it doesn't seem as luxurious as it once did. I really like this one better."
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"I think the Glow Recipe cushion cream is a competitor to probably the Drunk Elephant Protini cream. [...] For some reason something in that product changed, [...] I have no idea [...] if they changed the formula or something else [...] changed, but now every time I put it on it just foams up and takes like 2 minutes to settle down."
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"I would prefer over the Drunk Elephant Protini every single day. I don't know what happened to Protini, but something changed in it. It just brasses up every time I apply it."
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"I've had a little bit of issues with the Protini foaming up before, especially in a routine with vitamin C, but I didn't have any issues with that today. It applied really nicely, it doesn't look too greasy, it looks like a nice natural finish, and there's no fragrance in it, and it's got some nice anti-aging peptides. The Protini played great over my vitamin C serum, I don't know why I had issues with it foaming up before, but it seems to be a winner today."
~Yay
"The Drunk Elephant Protéini also contains copper peptides, which is why that moisturizer performs the way it does. [...] It's one of the most well-formulated options on the shelf. For fine lines and surface texture, if you're in Sephora and you want something you can grab today, it's a solid signal peptide complex option."
~Yay
"Drunk Elephant Protini Polypeptide Cream."
All 2 takes from Beyond50Skin
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"Drunk Elephant Protini Polypeptide Cream."
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"I had this in a little kit that I got for Christmas. This has never been one of my favorite creams, but it was just a convenience at the time. I thought why not give it another try. Again, it's probably best for normal skin types. There's nothing really special about this formula that makes my skin look any different. It's just a basic moisturizer. So this will not be a repeat purchase for me."
~Yay
"The Drunk Elephant Protini Polypeptide Cream combines multiple signal peptides with moisturizing amino acids and growth factors for improved texture, tone, and firmness. It's really lightweight, more like a gel cream texture that absorbs really quick. It's suitable for most skin types. It offers that immediate hydration and that bouncy feel which improves firmness over time."
~Yay
"This product is probably one of my favorites from them. The Protini Polypeptide Cream. It's really nice. This is looking attractive with vitamin E and beta size sterile squalane omega 9. Pretty substantial jar here. I'd be excited to give that a try."
All 3 takes from Dr Dray
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"This product is probably one of my favorites from them. The Protini Polypeptide Cream. It's really nice. This is looking attractive with vitamin E and beta size sterile squalane omega 9. Pretty substantial jar here. I'd be excited to give that a try."
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"There are a lot of Drunk Elephant products that are quite good. I enjoy the Protein Polypeptide Cream."
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"This polypeptide cream is called Protini, it's got peptides in it which help with hydration, and I've always liked this, it's kind of got a nice emollient effect to it."
~Yay
"If you don't like the feel of thicker creams, there is a really lightweight gel moisturizer that I gravitate to towards the summer time. It's the Drunk Elephant Protini Polypeptide Cream. This is a lovely gel cream that is great for summer or great for anyone that doesn't like richer creams or have more like oily and combination skin."
All 3 takes from Dr. Jenny Liu
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"The Protini Polypeptide Cream is a lightweight gel moisturizer with a blend of peptides that helps to hydrate the skin, nourish the skin without heaviness. It absorbs instantly and is a lightweight gel cream."
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"If you don't like the feel of thicker creams, there is a really lightweight gel moisturizer that I gravitate to towards the summer time. It's the Drunk Elephant Protini Polypeptide Cream. This is a lovely gel cream that is great for summer or great for anyone that doesn't like richer creams or have more like oily and combination skin."
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"Protini Polypeptide Cream is one of my favorite moisturizers from Drunk Elephant. It's this lightweight gel cream, so certainly for the wintertime it's better suited for oily combination skin, but it's lightweight, helps to hydrate without leaving any heaviness."
~Yay
"This cream is more like a moisturizer because it's not that emollient, one pump and it's lightweight. It's not something that's going to stay on your face, it absorbs very easily. It's an absolutely beautiful formula. It is pretty iconic because I've loved this product for a very long time primarily because peptides and I believe in peptides a lot. I would like to have peptides in every part of my skincare routine including the moisturizer, which is why this is good."
All 5 takes from Nipun Kapur
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"Drunk Elephant Protini Polypeptide Cream, and this is something I've used I love it. You have 10 peptides and this is only $80."
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"The Drunk Elephant Protini Polypeptide Cream is a fabulous fabulous product. You get a lot of hydration, so even if you've got a disrupted skin barrier this product just works like a charm. This is something that I have really enjoyed."
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"I feel that this is a cream that really enhances anti-aging impact nine different types of peptides that is what you get in the Drunk Elephant Protini Peptide Cream"
Translated from the guru's original language.
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"The Protein Peptide chef kiss it is one of the best products from Drunk Elephant"
Translated from the guru's original language.
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"This cream is more like a moisturizer because it's not that emollient, one pump and it's lightweight. It's not something that's going to stay on your face, it absorbs very easily. It's an absolutely beautiful formula. It is pretty iconic because I've loved this product for a very long time primarily because peptides and I believe in peptides a lot. I would like to have peptides in every part of my skincare routine including the moisturizer, which is why this is good."
~Nay
"While some batches of the [...] Protini Polypeptide Cream lack a preservative system, tests actually revealed the presence of yeast, such as Candida parapacillosis and bacteria related to the bacteria it was found. [...] They were actually all microorganisms that are commonly found on the human skin and in the environment, but they can cause infections, particularly in immunocompromised individuals or those with compromised skin."
All 2 takes from James Welsh
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"While some batches of the [...] Protini Polypeptide Cream lack a preservative system, tests actually revealed the presence of yeast, such as Candida parapacillosis and bacteria related to the bacteria it was found. [...] They were actually all microorganisms that are commonly found on the human skin and in the environment, but they can cause infections, particularly in immunocompromised individuals or those with compromised skin."
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"Standout products for them like their C Firmer vitamin C serum, Protini Polypeptide Cream and the TLC Sakuri Baby Facial really helped fuel this growth and kind of helped cement the brand's status as a staple of the skincare world in less than a decade."
~Yay
"This is an empty Drunk Elephant Protini Polypeptide Cream so I have the packaging in my bathroom and because I have that every time I finish the cream I just go and purchase the refill sizes so that I can just interchange them. It's full of peptides there's growth factors in here great for signs of aging and to firm the skin and it's also very lightweight and moisturizing and I just absolutely love this cream and I use it pretty much every day twice a day."
Top Pick: peptide cream
All 15 takes from Sincerely Miss Ash
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"I love this cream so much because it has nine types of peptides which really helps to address signs of aging. It can firm the skin, stimulate new collagen, and it has growth factors as well. But I also feel like it is very lightweight, it's not heavy in the least, and it's moisturizing enough even for the summer months. All I generally do is like half a pump during the summer because that's all I need for my combination skin, and then in the winter months I'm a little bit more generous."
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"This has been my go-to for several, several months. I was using this last year a lot as well and it's one of my favorite products because it performs really well in terms of keeping your skin moisturized and there's a lot of anti-aging ingredients in here to really help firm the skin and address signs of aging. There are nine types of peptides in here, there's also growth factors and the list goes on. This is jam-packed with so many wonderful ingredients to really help with signs of aging."
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"This is very moisturizing but it also has nine types of peptides to address signs of aging and to help firm the skin and to help produce new collagen. I keep going back to this one because I really do see a difference with my skin when I am consistent with this. I love the pump style packaging with that little button push down. The formulation is truly on point. Although I do wish it was a little bit more affordable, other than that I have nothing negative to say about this."
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"This has been my go-to cream as of late. I will use this in my morning and I will use this at nighttime sometimes. This one has nine types of peptides, so great for signs of aging and to firm up the skin. I love pairing this up with peptides or with serums, and I do pair this up at night time or with a retinol. This really is a great moisturizer that you can use everyday twice a day and it pairs up so nicely with a lot of ingredients and products."
IF I COULD ONLY PICK 1 PRODUCT FROM MY FAVORITE SKINCARE BRANDS | FYI...THIS WAS REALLY HARD!
"I've been using this one the most as of late and I'm really impressed with this. This has been a favorite for a really long time. [...] The texture is so thin and lightweight but it's so moisturizing, great for all skin types. There are nine types of peptides in here and of course there are other additional ingredients that are great to keep the skin moisturized as well. I feel like this really is one of the best from Drunk Elephant."
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"This [...] really is one of the best peptide creams. It really helps to create more of that firmness with the skin, it also addresses fine lines, but it's extremely moisturizing. This is perfect for all skin types including dry, including oily skin. I have combination skin, I am acne prone, this doesn't break me out. This is still moisturizing enough to keep my skin comfortable, but it's also very lightweight and it never interferes with my sunscreen nor with my makeup."
BEAUTY PRODUCT'S I'VE USED UP || SKINCARE, MAKEUP AND HAIRCARE - BEAUTY EMPTIES 2024
"This is an empty Drunk Elephant Protini Polypeptide Cream so I have the packaging in my bathroom and because I have that every time I finish the cream I just go and purchase the refill sizes so that I can just interchange them. It's full of peptides there's growth factors in here great for signs of aging and to firm the skin and it's also very lightweight and moisturizing and I just absolutely love this cream and I use it pretty much every day twice a day."
MY MORNING ANTI-AGING SKINCARE ROUTINE - A.M. SUMMER SKINCARE ROUTINE USING VITAMIN C
"I love the Drunk Elephant Protini Polypeptide Cream. You guys know that I use this a lot in my nighttime routine but I will occasionally use this in my morning routine as well. [...] Just that little amount locks in all of that moisture that we just applied with all of those serums and it just gives this nice glow to the skin as well, which I'm a big fan of."
MY MORNING ANTI-AGING SKINCARE ROUTINE | A.M. WINTER SKINCARE ROUTINE | OVER 30 SINCERELY MISS ASH
"For a face moisturizer I'm going in with the Drunk Elephant Protini Polypeptide Cream because my skin isn't too dry and tight right now. I've been using this pretty much every day since the beginning of December. A little bit goes a long way, it spreads nicely, and your skin has this beautiful glow to it. It sits nicely underneath sunscreen and makeup. It's a little bit more lightweight but it's still quite moisturizing."
BEAUTY EMPTIES 2023 | PRODUCT'S I'VE USED UP.. WILL I REPURCHASE?
"It keeps the skin super moisturized. I have combination skin and even during the winter months when my skin can become quite dry and tight, this is still enough moisture to keep my skin comfortable. Whether you have dry skin, whether you have oily combination skin, honestly I feel like this is great for all skin types. Yes, it's expensive, it really is expensive, but I'm really really obsessed with this."
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"It has that nice push down style packaging. I use this with retinol, peptides, copper peptides, when I'm using vitamin C, I'm using this with it, and I just love the way that this performs on my skin. If you feel like for some reason this is a little bit too heavy, which I feel like it isn't, but of course we're all different, then use this at night. But this really is great in the morning. I actually used it today. This is actually part of my everyday morning routine at the moment."
MY NIGHTTIME ANTI-AGING SKINCARE ROUTINE - P.M. SUMMER SKINCARE ROUTINE USING TRETINOIN
"I really love this moisturizer for the summer especially because I feel like it's really lightweight. I've been using this for a really long time, [...] in the winter months as well. It requires just a little amount because it's so effective. I've noticed that I can use it on my neck [...] without irritation, [...] and I do not get any irritation. [...] I mean, with consistency and with just time, I feel like your skin can adjust to this, even if you're someone with really sensitive skin."
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"I use the proteiny polypeptide cream all the time sometimes twice a day almost on an everyday basis and I know I will get a lot of use out of this"
MY NIGHTTIME ANTI-AGING SKINCARE ROUTINE | P.M. SUMMER SKINCARE ROUTINE | OVER 30
"The Drunk Elephant Protini Polypeptide Cream is very lightweight but it's moisturizing, and this has nine different types of peptides so peptides are great for signs of aging as well. I love pairing up peptides with retinoids. This cream is also perfect for all skin types including dry skin. When my skin is at its driest, I feel like this does an excellent job to keep the skin comfortable, but if you have oily skin I think you will also really like this because it is lightweight."
SEPHORA HOLIDAY SALE 2024 WISHLIST 🎁 | SKINCARE, MAKEUP AND HAIRCARE! - SINCERELY MISS ASH
"This is one of my go-to creams I use it in the morning I use it at night time it's full of peptides growth factors great for signs of aging and to firm the skin and it's quite lightweight but it's also very moisturizing at the same time"
~Mixed
"The Drunk Elephant Protini Polypeptide Cream is $69 for 1.7 oz and I believe it has all the exact same peptides in it as the comparable peptide cream at a lower price point."
~Mixed
"But because the brand avoids silicones I don't think [...] this buffs into your skin very nicely, it's [...] slow and kind of tricky. That's actually the reason I don't think I'm going to buy this again. [...] So while I do like this and understand why it's their bestseller, it's going to be the last time that I buy it."
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"But because the brand avoids silicones I don't think [...] this buffs into your skin very nicely, it's [...] slow and kind of tricky. That's actually the reason I don't think I'm going to buy this again. [...] So while I do like this and understand why it's their bestseller, it's going to be the last time that I buy it."
Skincare Empties: the Sunscreen Edition!
"Ultimately I like the Drunk Elephant Protini Polypeptide Cream. I've bought it at good deals, and I like that it has some EGF ingredients as well. It's not actually as cosmetically elegant as you would think though. [...] It's not bad, it's just that there really are nicer creams."
~Nay
"It definitely felt nice on application just didn't hold up throughout the day for me. [...] It's a middling moisturizer in my opinion at best. [...] I don't think there's anything in here that's bad, I just don't understand the price and I don't understand why it got hyped up, especially for the young crowd."
~Mixed
"The polypeptide moisturizer from Drunk Elephant is a $68 debacle and while it's not terrible you could use it on young skin because it has peptides which are naturally found in the human body, it's $68."
~Mixed
"This is a peptide cream that firms the skin, helps fight against premature aging, and deeply moisturizes. The combination of firming, aging-focused ingredients with the unique texture is the reason why it's so popular. It truly is a very unique formula, and it was really hard to find a dupe for."
~Nay
"Now if you put olive oil in your skin it's going to feel like this, it'll feel good. But hey, you are overpaying for this product. You know it's marketed as a polypeptide cream, but the peptides are so low down on the ingredients list that it may as well not be a peptides cream. It's basically an olive oil cream."
~Mixed
"A product that comes to mind is Drunk Elephant's Protini Polypeptide Cream, it's a very lightweight cream, there is no scent. Do I really think that this is going to help make my neck into the lamp pool that it should be on the street? Nope I do not but I might as well just use it because I have it."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Drunk Elephant Protini Polypeptide Cream?

A lightweight gel-cream moisturizer combining multiple peptides, amino acids, and growth factors designed to hydrate, firm skin, and improve texture.

Is Drunk Elephant Protini Polypeptide Cream worth it?

The gurus are split. 9 of the 18 gurus give it their stamp of approval while 3 would skip it, which lands it in the middle at a Guru Score of 65%.

What is Drunk Elephant Protini Polypeptide Cream's Guru Score?

Drunk Elephant Protini Polypeptide Cream holds a Guru Score of 65%. That is our read on how warmly the experts talk about it, based on the verdicts of 18 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

Who is Drunk Elephant Protini Polypeptide Cream best for?

Drunk Elephant Protini Polypeptide Cream is generally suited to mature skin.

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