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ISDIN Eryfotona Actinica SPF 50.

ISDIN Eryfotona Actinica SPF 50
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Sunscreen
#16 in SunscreenSee the ranking →
About this product

A mineral sunscreen with SPF 50 and DNA repair enzymes, designed to protect skin and help reverse existing sun damage.

Full ingredients

Zinc Oxide (11%), Water, Diethylhexyl Carbonate, Dibutyl Adipate, Cyclopentasiloxane, Dicaprylyl Carbonate, Alcohol Denat, Cyclohexasiloxane, Butylene Glycol, PEG-30 Dipolyhydroxystearate, Nylon-12, PEG-10 Dimethicone, Dimethicone, Sodium Chloride, Phenoxyethanol, Disteardimonium Hectorite, Triethoxycaprylylsilane, Tocopheryl Acetate, Glyceryl Stearate, Fragrance, Bisabolol, Disodium EDTA, Ethylhexylglycerin, Panthenol, PEG-8, Tocopherol, Lecithin, Plankton Extract, Ascorbyl Palmitate, Ascorbic Acid, Citric Acid

More from ISDIN 5 products · Guru Score 92% →

Guru Score

80%

Yay

10 experts · Strong agreement

What the gurus are saying

The DNA repair enzymes and mineral formula earn consistent praise, especially for those with sun-damaged or actinic skin. The lightweight texture and minimal white cast stand out, it absorbs quickly and layers beautifully under makeup, though a few gurus note you may need extra product because of how runny it is. The main trade-off: it's pricey and contains fragrance that bothers some people, and while dermatologists find it compelling, they don't consider it standard of care yet.
Synthesized from 10 expert reviews · most recent take July 2026

What they liked

  • DNA repair enzymes reduce existing sun damage
  • Lightweight, fast-absorbing mineral formula
  • Minimal white cast, blends seamlessly

What they flagged

  • Not particularly moisturising for dry skin
  • Expensive at $60 for 3.4 oz

Best for

Type

SunscreenCream

Key actives

Vitamin CVitamin ESPF

Formula notes

Contains fragranceContains drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
✓Yay
"It blends in very well, only one tint though. I really like that it has the DNA repair mechanism, since as we get UV radiation damage and get older we aren't as good at picking up DNA repair mistakes. It's also packed with antioxidants, so you're paying more for it, but it's a great reliable brand. I recommend it to patients a little older, after age 40 or 45, dealing with pre-skin cancers to full-on skin cancer tumors."
All 4 takes from Dr. Daniel Sugai
Dermatologist Reviews: The Best Sunscreens of 2024
"Consider this if you have mature skin and you're going to your dermatologist and they're spraying you with liquid nitrogen quite a bit, consider the ISDIN Eryfotona Actinica sunscreen"
3 BIGGEST Skincare Regrets I See in Clinic | Dermatologist Explains
"We want to snip those out as much as possible, but as we get older we have a less efficient system in taking out those mutations and the system gets overwhelmed and that leads to tumors. So I recommend the ISDIN Eryfotona Actinica tinted or non-tinted, [...] those emulsion sunscreens are very good. Just shake them up well to distribute the UV filters evenly throughout before applying."
Dermatologist Reviews: Holiday Skincare Picks for All Ages 2023
"If you're say 40s 50s 60s and you're dealing with pre-skin cancers or skin cancers I recommend isin aona tinted Sun screen that's been good because that helps with DNA repair the aerona in it"
The Best Tinted Sunscreens of 2026
"It blends in very well, only one tint though. I really like that it has the DNA repair mechanism, since as we get UV radiation damage and get older we aren't as good at picking up DNA repair mistakes. It's also packed with antioxidants, so you're paying more for it, but it's a great reliable brand. I recommend it to patients a little older, after age 40 or 45, dealing with pre-skin cancers to full-on skin cancer tumors."
✓Yay
"The ISDIN Eryfotona, beautiful sunscreen."
All 2 takes from HotandFlashy
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"This next sunscreen is an SPF 50, but it's much more expensive. [...] I love everything about it except that it has so much fragrance in it. I can't wear it because of all the fragrance, but I know people love it."
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"The ISDIN Eryfotona, beautiful sunscreen."
✓Yay
"It's a pure mineral sunscreen along with the DNA repair enzyme. It also has vitamin E that's an antioxidant. It's a liquid kind of texture, absorbs really quickly and leaves minimal white cast. It's [...] great for those with more immature skin, wanting to not only protect their skin, but also reduce some of the pre-existing sun damage that you have."
All 3 takes from Dr. Jenny Liu
Sephora Sale Must-Haves | Dermatologist-Approved Skincare & Haircare | Dr. Jenny Liu
"It's a pure mineral sunscreen along with the DNA repair enzyme. It also has vitamin E that's an antioxidant. It's a liquid kind of texture, absorbs really quickly and leaves minimal white cast. It's [...] great for those with more immature skin, wanting to not only protect their skin, but also reduce some of the pre-existing sun damage that you have."
Dermatologists Answer Sunscreen Questions
"One of my two favorites at the moment is the ISDIN Eryfotona Actinica, which is a mineral based sunscreen. It's made in Spain and it contains these really unique DNA repair enzymes that help to reverse DNA damage from the sun, so that's pretty cool. It rubs in really well, ultra lightweight. Mineral sunscreens get a bad reputation because they can leave a white cast, so I'm really picky, and this one is very elegant, it does not leave a white cast at all."
Your Skin After 40: A Derm’s Guide to Menopause & Perimenopause Skincare | Dr. Jenny Liu
"It's a Spanish brand, they make elegant sunscreens, and this one is really popular among dermatologists because not only is it a pure mineral filter, great for anyone with dry and sensitive skin, it's lightweight and elegant, fluid like, but does not leave a white cast. I believe it's also water resistant, but it's got high SPF protection, SPF 50, but also has this unique DNA repair zone that [...] helps to repair DNA damage that has basically happened or accumulated in your skin."
✓Yay
"They're sunscreens. They have a tinted sunscreen and a non-tinted sunscreen here in the US with DNA repair enzymes. So definitely something of interest, but they're kind of expensive. [...] I don't think it is a must-have. It's not like something that is in the guidelines for treating patients who have a history of non-melanoma skin cancer moving forward. It's not standard of care, but it is a compelling angle."
All 2 takes from Dr Dray
Beyond Sunscreen: The Ultimate Guide to Photoprotection for Your Skin
"They're sunscreens. They have a tinted sunscreen and a non-tinted sunscreen here in the US with DNA repair enzymes. So definitely something of interest, but they're kind of expensive. [...] I don't think it is a must-have. It's not like something that is in the guidelines for treating patients who have a history of non-melanoma skin cancer moving forward. It's not standard of care, but it is a compelling angle."
ANTI-AGING DNA REPAIR ENZYMES 🤔 ISDIN Eryfotona SUNSCREEN REVIEW @DrDrayzday
"It leaves a pretty sheer white cast, it's not chalky at all. It's really nice in terms of application consistency, it leaves the skin moisturized but not greasy, so it's a great base for cosmetics, and it's also a great matte option if you have oily skin. It's lightweight and fast absorbing. It does have alcohol denaturant in it, which some people are fearful of or find drying, but [...] it allows for a quicker dry formula and lets sweat evaporate so it helps you feel less overheated."
✓Yay
"It has this really fast absorbing, lightweight texture that doesn't peel under makeup. Initially when you put it on, you might [...] notice a little bit of a white cast, but the more you rub it in, it really does go away. This is mineral-based broad spectrum UVA UVB coverage, contains zinc oxide, and it really layers very well under makeup, BB creams, anything else you want to put on top of it. It also contains vitamin E for that antioxidant protection against free radicals."
All 2 takes from Tea with MD
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"It has this really fast absorbing, lightweight texture that doesn't peel under makeup. Initially when you put it on, you might [...] notice a little bit of a white cast, but the more you rub it in, it really does go away. This is mineral-based broad spectrum UVA UVB coverage, contains zinc oxide, and it really layers very well under makeup, BB creams, anything else you want to put on top of it. It also contains vitamin E for that antioxidant protection against free radicals."
A Dermatologist's Summer Skincare Guide | Top Products Picks
"The non-tinted version is the ISDIN Eryfotona Actinica SPF 50, and this one I actually worked with them a couple months ago in New York but they're obviously not sponsoring this video, I'm not being paid to say this, but it just contains this really amazing technology. All of their sunscreens contain these unique DNA repair enzymes called photolyase, which actually helps to repair DNA damage from the sun."
✓Yay
"This is the ISDIN Eryfotona Actinica SPF 50 and this is so good, it is phenomenal, especially if you have actinic keratosis. ISDIN specifically designs these products for actinic damage and this is a mineral formula. You got to shake, shake, shake it because of how lightweight and liquidy this is."
All 2 takes from Cassandra Bankson
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"This is the ISDIN Eryfotona Actinica SPF 50 and this is so good, it is phenomenal, especially if you have actinic keratosis. ISDIN specifically designs these products for actinic damage and this is a mineral formula. You got to shake, shake, shake it because of how lightweight and liquidy this is."
Does The SPF 2 Finger Rule Actually Work??
"This one from ISDIN is fantastic, it's tinted and it's actually mineral. Just because it's mineral doesn't mean it's going to be more pasty—a lot of people assume that but sometimes mineral formulas can be super lightweight. [...] This one is really runny, so you might need three if not four, maybe even six finger rule with this one."
✓Yay
"The ISDIN Eryfotona Actinica sunscreen has DNA repair enzymes and sunscreens are such an easy way to incorporate them into your routine"
✓Yay
"I'm using this one myself, the Isdin Eryfotona Actinica. It's super popular, and it's not an inexpensive sunscreen, but it's one hundred percent mineral."
✓Yay
"Another untinted mineral sunscreen that I really like is the ISDIN Eryfotona Actinica SPF 50. It's a [...] really good mineral option, both because it goes on really seamlessly and because it plays well under makeup. I will say this does leave a little bit of a white cast on my skin, but I'm typically wearing it under a little bit of foundation or tinted moisturizer, and that cancels that out. This uses 11% zinc oxide as the mineral filter, and it's water resistant for 40 minutes."
✓Yay
"Isdin has their Eryfotona Actinica, a zinc oxide sunscreen loaded with DNA repair, so it not only protects from future sun damage but also helps reverse the sun damage you already have."
Sponsored
All 4 takes from Dr. Shereene Idriss
Anti-Aging Skincare for 50s+, Mature Skin, & Menopause | Dr. Shereene Idriss
"But there are two sunscreens on the market that have an ingredient known as photoliase that helps to reverse the damage of your skin that's been already done by the sun it helps to reverse it these two are is den"
How to Prevent Skin Thinning & Boost Your Collagen! From a Dermatologist | Dr. Shereene Idriss
"They're mineral with zinc, vitamin E, and they are lightweight, they are super super light. You have to shake it and it's like light, okay, very very lightweight to get the coverage that you need so you don't feel like your skin is suffocating. That is the number one way that you are going to protect your skin over time, especially if you start at a young age."
Best of Sephora Spring Sale 2025 | Dermatologist Picks by Dr. Shereene Idriss
"Isdin has their Eryfotona Actinica, a zinc oxide sunscreen loaded with DNA repair, so it not only protects from future sun damage but also helps reverse the sun damage you already have."
Best Sunscreens for All Skin Types: Dry, Oily, Sensitive, & More! | Dr. Shereene Idriss
"She also needs to be shaken and not stirred and it is a zinc oxide. [...] The reason why this one is better for anti-aging purposes is because it is formulated with a proprietary patented DNA repairasomes which help to repair existing sun damage. So if you have a lot of pre-cancerous lesions also known as actinic keratoses or a lot of sun damage on your face, this is not only protecting but is being proactive in helping you fix your skin in the process."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Vitamin C

Topical vitamin C is an antioxidant with reasonable evidence for dullness and uneven tone. It breaks down in light and air, so how a product is formulated and packaged matters as much as the percentage on the front.

Source: DermNet

Sunscreen filters

Sun protection is the best evidenced way to slow visible ageing, and the filters are what does the work. Mineral and chemical filters both protect when a product is applied thickly enough and often enough, which is where most people fall short rather than on the choice of filter.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Frequently asked.

What is ISDIN Eryfotona Actinica SPF 50?

A mineral sunscreen with SPF 50 and DNA repair enzymes, designed to protect skin and help reverse existing sun damage.

Is ISDIN Eryfotona Actinica SPF 50 worth it?

Yes. All 10 gurus who reviewed it give it their stamp of approval, for a Guru Score of 80%.

What is ISDIN Eryfotona Actinica SPF 50's Guru Score?

ISDIN Eryfotona Actinica SPF 50 holds a Guru Score of 80%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 expert reviewers we have collected.

Who is ISDIN Eryfotona Actinica SPF 50 best for?

ISDIN Eryfotona Actinica SPF 50 is generally suited to sensitive skin.

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