Medicube PDRN Pink Peptide Serum: a Guru Score of 62%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

~Yay

"I went through two of these as well. [...] I love this. It's one of the first things that I use after microneedling when I start adding skincare back into the mix. Love, love, love this."

All 7 takes from Darnell Cox | 50+ Healthy Aging Expert

Over 30 and ready to master the ultimate EVENING skincare routine? 🎙️Join me for an IG Live Show

"This is by Medicube. It's called PDRN Pink Peptide Serum that has changed my skin. I'm not kidding."

Curious about peptides? 👀✨ Are they actually worth it… or just another skincare trend? 🎙️ Watch

"This is salmon sperm. This is a multi-peptide by Medicube. It's [...] PDRN Pink Peptide Serum. So it's got multiple peptides in it, but it also has nucleotides derived from salmon sperm. [...] The nucleotides in salmon sperm very closely match the nucleotides found in our skin. When we have genetic gaps, we're missing something, that's a sign of aging. [...] When your genes aren't replicating exactly how they're supposed to, that's a sign of aging."

Over 30 and ready to master the ultimate skincare routine? 🎙️Join me for an IG Live Show where

"I love a PDRN, this pink peptide by Medicube, the salmon sperm peptide. It works because the nucleotides of salmon sperm mimic the nucleotides in our skin, filling in genetic [...] gaps to make skin more resilient [...] and function better."

10 Step Skincare Routine for “Glass Skin”✨ 🎙️On yesterday‘s live show I went over skincare 101

"I like this PDRN by Medicube. This is part of the evening routine that I'm doing right now."

Want to biohack your skin to look AND function younger? 👀✨ Comment “CALENDAR” for my FREE 2026

"Let me give you an example, the Medicube PDRN serum. This is soothing and non-irritating, so it's one of the peptide products you can use right after micro needling without it stinging."

NuFACE or ZIIP HALO? Let’s look at the science

"But then I will also, so here's my thing that I've been doing at night for the neck. I'll be doing the Medicube pink PDRN serum, the one skin first to uh handle those senescent cells um to get rid of those zombie cells, right? Clear the way. And that peptide is a great it's pink that is great for soothing of the neck."

LET’S TALK K-BEAUTY! ✨🇰🇷 If there’s one thing I’m NOT coming home from South Korea without… it’s

"I went through two of these as well. [...] I love this. It's one of the first things that I use after microneedling when I start adding skincare back into the mix. Love, love, love this."

Hyram

4.33M subs

~Nay

"But yeah, that serum I just can't get behind because the fragrance."

Mad About Skin

732k subs

~Yay

"Medicate do one of my favorites."

No BS Beauty

89k subs

~Nay

"This stuff smelled so strong, just floral perfumey. It was just too much. [...] The ingredients looked fine except for fragrance right in the middle and the fragrance was strong and it was overwhelming and it gave me the beginning of a migraine. So I didn't apply it on my face."

All 2 takes from No BS Beauty

Trying The Popular Viral Medicube Skincare Products & Science Based Alternatives

"This one has a small amount of sodium DNA, which is the PDRN that they mentioned. Sodium DNA is based from typically salmon. It contains DNA fragments, long chains of nucleotides that help support and repair and regenerate the skin. It also contains turmeric, ubiquinone, and five peptides, which are at the very end of the ingredient list. Aside from the fragrance, if it didn't have the fragrance in here, I'd probably be using it. [...] The strong scent is way way too much for my migraines."

Skin Care I Wanted to Love But Cannot 💔 Strongest Scented Skincare Products

"This stuff smelled so strong, just floral perfumey. It was just too much. [...] The ingredients looked fine except for fragrance right in the middle and the fragrance was strong and it was overwhelming and it gave me the beginning of a migraine. So I didn't apply it on my face."

Dr. Jenny Liu

324k subs

~Yay

"It actually does contain salmon PDRN with a peptide complex and niacinamide to overall improve skin texture, tone, and help with skin rejuvenation. It's really aimed at improving the quality of your skin, the appearance of fine lines, wrinkles, dullness, hydrating your skin, improving overall even tone. It is hypoallergenic and suitable for sensitive skin."

Top Pick: peptide serum

All 2 takes from Dr. Jenny Liu

K-Beauty at Ulta: What’s Actually Worth Buying?!? | Dermatologist's picks | Dr. Jenny Liu

"It actually does contain salmon PDRN with a peptide complex and niacinamide to overall improve skin texture, tone, and help with skin rejuvenation. It's really aimed at improving the quality of your skin, the appearance of fine lines, wrinkles, dullness, hydrating your skin, improving overall even tone. It is hypoallergenic and suitable for sensitive skin."

Salmon sperm injections, is PDRN Worth the Hype? | Derm explains; Dr. Jenny Liu

"It contains salmon sperm DNA peptide complex that works complimentary to the salmon sperm to enhance skin firmness and resilience. And niacinamide has so many great benefits with skin barrier support, improving texture as well as brightening the skin. So this one of all the ones that I've used is really one of my personal favorites."

Dr. Aleksandra Brown

151k subs

~Yay

"It's super lightweight hydrating serum. Helps improve even tone and boost elasticity for like that firmer, more radiant complexion. It absorbs pretty fast. I like to use it on top of my toner. It leaves you feeling really hydrated, plump. I do like moisturizer on top of it because I feel like it might be a little sticky otherwise, but I find a lot of serums sticky. [...] This one's great if you have dry skin, want hydration."

All 2 takes from Dr. Aleksandra Brown

PDRN in Skincare: What It Is, How It Works, and If It's Worth It | Dermatologist Explains

"The key ingredients is the salmon PDRN at 10,000 parts per million, five peptide complex, and holy basil leaf extract. [...] I find it to be just a little bit more hydrating. As a matter of fact, I have found it to be a little bit too hydrating to do videos like YouTube because I end up being too glowy. So, if you're somebody who's extra dry and you want like the best over-the-counter and you want to try PDRN, I would probably try the Medicube."

Derm-Approved Prime Day Skincare Deals You Shouldn’t Miss | What to Buy (and Why)

"It's super lightweight hydrating serum. Helps improve even tone and boost elasticity for like that firmer, more radiant complexion. It absorbs pretty fast. I like to use it on top of my toner. It leaves you feeling really hydrated, plump. I do like moisturizer on top of it because I feel like it might be a little sticky otherwise, but I find a lot of serums sticky. [...] This one's great if you have dry skin, want hydration."

Nipun Kapur

412k subs

~Nay

"Just doesn't cut it for me. If you are in your 20, early 30s you can use it. Don't expect miracle it is just a nice hydrating product. But if you are oily acne prone this is not for you"

Translated from the guru's original language.

All 2 takes from Nipun Kapur

Science or Scam: Do PDRN Serums Really Work? Best PDRN Serums in India | Nipun Kapur

"Medicube is something that can give you a lot of nourishment. It can give hydrate and moisturize your skin well. But if you're looking at the true magic of PDRN, and you will not know the magic of PDRN unless you have used a high quality product, Medicube is really a 5 on 10. From an anti-aging perspective, it is really a 5 on 10."

Best PDRN Products for Anti-Aging | Review of Anua, Medicube & VT Cosmetics | Nipun Kapur

"Just doesn't cut it for me. If you are in your 20, early 30s you can use it. Don't expect miracle it is just a nice hydrating product. But if you are oily acne prone this is not for you"

Translated from the guru's original language.

CYoung

95k subs

~Yay

"I tried the new disposable Medicube PDRN serum, it has a little scent but not too crazy, and a thick texture that kind of films on the skin. If you have oily combo skin it can feel kind of heavy, but if you use the massage device with it, it slides in really well and goes inside nicely. The PDRN amount is a lot higher compared to Anua, and it feels bouncy, which makes it great to use as a makeup primer."

All 3 takes from CYoung

I Tested 10 NEW Viral K-Beauty Products — Which Ones Are ACTUALLY Worth It?

"I tried the new disposable Medicube PDRN serum, it has a little scent but not too crazy, and a thick texture that kind of films on the skin. If you have oily combo skin it can feel kind of heavy, but if you use the massage device with it, it slides in really well and goes inside nicely. The PDRN amount is a lot higher compared to Anua, and it feels bouncy, which makes it great to use as a makeup primer."

Blind Testing 16 Viral Serums 💥 Which Ones Are Worth It?!

"For me, this brand feels like a marketing company more than a cosmetic company, they make so many products and it's appealing on TikTok but maybe not in real life. But I'll admit this serum they made is okay, it has a lot more PDRN in it compared to the Anua PDRN serum, and even on my dry mature skin it felt pretty hydrating, they also do buy one get one promotions a lot at Olive Young. If you're curious about PDRN and want to try it, I'd say this isn't a bad choice, and it's cute too."

What You Should Know Before You Buy Viral Korean Skincare Products!

"It contains PDRN at 10,000 PPM, which is 1 percent, a pretty high percentage, and also niacinamide, peptides, and coenzyme Q10, so it's really good as an antioxidant. It absorbs pretty quickly, but the texture isn't super light, and I like that. If you're dry, mature skin over 40, starting to get aging and your skin is getting thinner, you'll like it even more."

AliceintheRabbitHole

59k subs

~Nay

"This just did not work for my skin type. I felt like I was getting an increase in redness when I used this product, though it's possible that came from the fragrance or the vitamin B12 ingredient rather than the PDRN itself, since this is a higher concentration than I'd knowingly tried up until this point. [...] So for me this is a no, I'm sure it will work for some amount of people, but it was sadly a no-go for me."

Kelly Driscoll

91k subs

~Nay

"And I just don't find this to be very compelling. I don't find it to be very worth it."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Medicube PDRN Pink Peptide Serum?

Medicube PDRN Pink Peptide Serum is a facial serum built around salmon-derived PDRN and a five-peptide complex, designed to hydrate skin and support its firmness, texture and even tone.

Is Medicube PDRN Pink Peptide Serum worth it?

The gurus are split. 5 of the 10 gurus give it their stamp of approval while 5 would skip it, which lands it in the middle at a Guru Score of 62%.

What is Medicube PDRN Pink Peptide Serum's Guru Score?

Medicube PDRN Pink Peptide Serum holds a Guru Score of 62%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.