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Medik8

Medik8 Oxy-R Peptides.

About this product

A serum containing 1% oxyresveratrol and tetrapeptide 30, designed to brighten skin, fade hyperpigmentation, and boost radiance. Comes as two separate bottles to maintain antioxidant stability.

Full ingredients

Aqua (Water), Butylene Glycol, Artocarpus Lakoocha Wood Extract, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium EDTA, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate

More from Medik8 20 products · Guru Score 94% →

Guru Score

89%

Yay

Early verdict · Few reviews so far

What the gurus are saying

Oxyresveratrol and tetrapeptide work together to block tyrosinase, the enzyme that produces melanin, making this particularly effective for stubborn hyperpigmentation and melasma that does not respond well to other treatments. Gurus praise it as a gentler alternative to prescription options like hydroquinone, especially for those too sensitive for vitamin C. The dual-bottle design keeps the antioxidant fresh throughout use, since antioxidants break down quickly once exposed to air.
Synthesized from 3 expert reviews · most recent take September 2026

What they liked

  • Fades stubborn hyperpigmentation and melasma
  • Gentle enough for sensitive skin
  • Two separate vials keep actives fresh

What they flagged

    Nothing. None of the experts who reviewed it raised a problem.

    Type

    Key actives

    Formula notes

    Fragrance-freeNo drying alcohol

    Where to buy

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    What the gurus are saying.

    Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

    All takes Yay takes Nay takes Mixed takes Hide sponsored
    ✓Yay
    "It needs to be super fresh because that's when you get the best results. So I love the packaging and the way that it works. Honestly, this is the quickest acting of all the hyperpigmentation antioxidants I have ever ever found. You get a month supply in one thing and honestly, you will see such results within that month that you can almost just use it as a way of kickstarting your hyperpigmentation routine and then you can just go into maintenance mode afterwards."
    Top Pick: hyperpigmentation booster
    All 6 takes from Mad About Skin
    SKINCARE OF THE YEAR 2025 - Best Black Friday Skincare Sales Im Buying
    "This, if you haven't tried it, is stunning for hyperpigmentation. It uses a potent antioxidant to really fight and fade that hyperpigmentation. A lot of people will traditionally reach for vitamin C's. They might opt for a high strength exfoliator or a retinoid. They're all great for hyperpigmentation, but the missing link might be a nice high strength antioxidant. And this one definitely delivers. Also has some brightening peptides in here, too. So, it's like a double whammy."
    4x BETTER ANTI AGING (You Wont Believe The Results) - Medik8 Review
    "It's just gone totally under the radar. Nobody talks about it, but I think it's a true holy grail for certain people. What this does is it uses oxyresveratrol, which is a patented antioxidant known for being able to really brighten and lift the tonality of the skin, but it also is fantastic at fading hyperpigmentation, particularly stubborn hyperpigmentation. My hyperpigmentation responds quite well to most things out there, so I'm not the best candidate to use this."
    10 Greatest ANTI AGING SERUMS - Skincare Awards 2025
    "I love everything Medik8 do in the anti-aging game and this to me has been a little holy grail. Couple of drops of this morning and night and your glow game will be on point and you'll be radiating to the gods in no time. It genuinely works. I know not everybody wants that boost to radiance and luminosity, that might not be their anti-aging goal, but if it's yours, this is where it's at."
    MOVE OVER VITAMIN C - This Hyperpigmentation Serum Blew Me Away
    "I've absolutely fallen in love. I did see results in the first four weeks, so they definitely get a tick against that claim, but I do feel that it took maybe two months for the full results to actually shine through. You see the initial results at that four-week point, but you're going to want to really use it for eight weeks before you actually see the full suite of results, which still in my opinion is super quick. [...] One box of this, two vials, does actually last two months."
    Official: WORLDS No1 SKINCARE BRAND - This Brand Transformed My Skin
    "One vial lasts two weeks, so you get [...] a month's supply. This is the best glow up hyperpigmentation fighting booster you will ever use. Once a year, usually [...] for the whole month of August, I use this antioxidant powered brightening system to turbocharge my hyperpigmentation, and by the time September comes around it's breaking apart. You can use it [...] year round, but I don't think I need to, it works so well I just use it for the month of August."
    Breakthrough HYPERPIGMENTATION UPDATE - 4 New Ingredients About To Change It All
    "It needs to be super fresh because that's when you get the best results. So I love the packaging and the way that it works. Honestly, this is the quickest acting of all the hyperpigmentation antioxidants I have ever ever found. You get a month supply in one thing and honestly, you will see such results within that month that you can almost just use it as a way of kickstarting your hyperpigmentation routine and then you can just go into maintenance mode afterwards."
    ✓Yay
    "This product is genius. I feel like I haven't talked about it enough and it deserves more attention. It has 1% oxyresveratrol, which is a very potent yet gentle antioxidant that has all of the beneficial antioxidant effects [...] but it also has the ability to inhibit tyrosine, which is an enzyme in our skin that produces melanin and pigment. When you block that enzyme from functioning, [...] you reduce that excess pigment formation."
    ✓Yay
    "Medik8 did clinical testing on the product from the fairest to the deepest skin tones and showed that it was effective at brightening the skin and fading hyperpigmentation in all skin types. The respiratory trials benefits definitely do extend beyond tackling dark spots and hyperpigmentation. It has the anti-inflammatory benefits of soothing and calming the skin, it has the antioxidant ability to fight against environmental stressors, and it does have anti-aging abilities."
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    What the evidence says.

    Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

    Alpha hydroxy acids

    Alpha hydroxy acids loosen the bonds holding dead cells at the surface. The evidence supports smoother texture and more even tone over time, and they can leave skin more sensitive to sun.

    Source: NIH, National Library of Medicine

    Humectants and emollients

    Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

    Source: DermNet

    Peptides

    Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

    Source: NIH, National Library of Medicine

    Frequently asked.

    What is Medik8 Oxy-R Peptides?

    A serum containing 1% oxyresveratrol and tetrapeptide 30, designed to brighten skin, fade hyperpigmentation, and boost radiance. Comes as two separate bottles to maintain antioxidant stability.

    Is Medik8 Oxy-R Peptides worth it?

    Yes. All 3 gurus who reviewed it give it their stamp of approval, for a Guru Score of 89%.

    What is Medik8 Oxy-R Peptides's Guru Score?

    Medik8 Oxy-R Peptides holds a Guru Score of 89%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

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