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NIOD

NIOD Copper Amino Isolate Lipid 1%.

About this product

A copper peptide product with a rich, lipid-based oil texture, designed to hydrate skin and support a plumper, more youthful look.

Full ingredients

Squalane, Caprylic/​Capric Triglyceride, Glycerin, Aqua (Water), Hydrogenated Starch Hydrolysate, Sucrose Laurate, Propanediol, Sucrose Stearate, Copper Tripeptide-1 Palmitamide, Glycolipids, Hydroxymethoxyphenyl Propylmethylmethoxybenzofuran, Vetiveria Zizanoides Root Extract, Aphanizomenon Flos-Aquae Extract, Hydroxymethoxyphenyl Decanone, Bisabolol, Biosaccharide Gum-1, Maltodextrin, Potassium Sorbate, Sodium Benzoate, Chlorphenesin, Phenoxyethanol

More from NIOD 16 products · Guru Score 88% →

Guru Score

69%

Mixed

6 experts · Moderate agreement

What the gurus are saying

Its thick texture, which loosens as you spread it, is what these gurus keep coming back to, and a tiny amount goes far. Many praise how quickly it works and how plump skin looks, though the high price puts some off. The one thing to keep in mind: a few broke out at first, and while some came around using it as the last nighttime step, others never got on with it.
Synthesized from 6 expert reviews · most recent take April 2026

What they liked

  • Spreads easily with minimal product needed
  • Hydrating oily base absorbs without residue
  • Lasts several months per tube

What they flagged

  • High price point at $93
  • Label peeling off the tube
  • May cause breakouts in reactive skin

Type

Key actives

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
~Yay
"They work absolutely fantastically, but when there's a sale on, I treat myself to this because I just love the feel of this product on my skin. This is a copper peptide in a lipid format, which is fairly unique and fairly rare. You don't see it a lot on the market, but those lipids will just help those copper peptides penetrate a little bit deeper. I find you get slightly quicker results with a lipid based copper peptide. [...] It gives you the nicest, smoothest skin. It's super hydrating."
All 12 takes from Mad About Skin
No1 Anti Aging - TOP 10 PEPTIDE SERUMS 2025
"This works in one of the quickest times possible. [...] A little goes such a long way with this product. You only need a tiny bit. It spreads beautifully on the skin because of that lipid oil base and it just is amazing. It's hydrating, but it has a super high concentration of a potent form of copper peptides. This will work really quick for you. The only reason it's not higher up on this list is it does come with a high price point. So it's not going to be for everyone's budget."
NIOD SALE ANNOUNCED - Up To 50% Off 😱 (My NIOD Favourites)
"I've [...] tried other copper peptide products but this is hands down the best on the market. [...] A little definitely goes a long way so be sparing with this, but it helps with the overall barrier health of the skin, gives you some great anti-aging benefit, and is a potent antioxidant and anti-inflammatory all in one. I personally [...] get better results from it for my skin type. It's a really great anti-aging option and I would recommend it to everyone."
2 X FIRMER SKIN - The Best Copper Peptides #skincare
"The copper Amino Isolate Lipid [...] is like the ultimate when it comes to copper peptides. This will give you everything you need. It's got a great delivery mechanism to make sure that those copper peptides get exactly where they need to be to deliver the maximum results. It's stunningly hydrating and has a great dose of those copper peptides. I think altogether this is the best on the market because of its price."
NIOD SALE ANNOUNCED - Up To 50% Off (My NIOD Favourites)
"This is one of the best formulated copper peptides you will ever find. It uses that lipid technology to make sure that those peptides get into the skin where they need to be in order to get maximum results, so you're getting like next level bang for your buck when it comes to these copper peptides. [...] A little goes such a long way, use the tiniest amount because when you spread it, it spreads beautifully on the skin. You don't need a lot to get those results."
10/10 PERFECT SKINCARE - Best Skincare 2024
"This is the Copper Amino Isolate Lipid from NIOD. The reason I'm giving this 10 out of 10 is it's truly unique, has that high dose of copper peptides, but it also has a delivery mechanism that makes sure that every single one of them gets to where they need to be in the skin to deliver that anti-aging benefit. If you like copper peptides but you want to get a little bit more from them, this is kind of the product for you because it's a lipid base."
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"Spread it over. It spreads beautifully. It feels great. And you only need to use it once a day. On an evening is when you're going to get the very best results from using this. It'll repair as you sleep and give you that collagen boost, which let's be honest, we all crave. Absolute holy grail, which I love, and I've gone to town on this this year because my skin loves it, and I don't want to be without it again."
ULTIMATE ANTI-AGING SKINCARE ROUTINE - My Evening Skincare Routine
"The NIOD Copper Amino Isolate Lipid is next level. Copper peptides boost collagen and elastin production, they're antioxidant and anti-inflammatory, so if you notice in winter that your skin becomes more inflammation prone or more redness prone, a copper peptide will really help with that. Three drops covers the whole face and gives you the results you want without wasting any product."
10 Greatest ANTI AGING SERUMS - Skincare Awards 2025
"My skin loves it. I never want to be without it. [...] It's just a guaranteed collagen boost in a jar. Because it's in a lipid formulation, that technology means those peptides get to where they need to be more effectively, so you have less wastage. You only need a tiny amount of this product. Don't overdo it. It's lipid based, so it spreads like butter on the skin. [...] Put a tiny amount, dot it round, spread it in. It'll last longer that way and it'll still give you amazing results."
SUPERCHARGED ANTI AGING - The Perfect Peptide Serum
"This is a fantastic product because it's in a lipid formulation, which means that it finds it really easy to get into the skin to where it needs to be for those copper peptides to deliver all that great benefit. The technology in here is genuinely next level. So you're going to see some really quick and next level results. [...] It spreads beautifully, almost like butter, so you can really get an even application without having to use a lot of product."
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"You could reach for traditional copper peptides which I absolutely love, something like this, the NIOD Copper Amino Isolate Lipid 1%. I covered copper peptides in an entirely separate video which I'm going to leave a link to up there, definitely one to check out because I think that copper peptides are the best studied and the best understood of the collagen promoting peptides out there."
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"They work absolutely fantastically, but when there's a sale on, I treat myself to this because I just love the feel of this product on my skin. This is a copper peptide in a lipid format, which is fairly unique and fairly rare. You don't see it a lot on the market, but those lipids will just help those copper peptides penetrate a little bit deeper. I find you get slightly quicker results with a lipid based copper peptide. [...] It gives you the nicest, smoothest skin. It's super hydrating."
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"Hands down, no competition. I love this. My skin just loves it. This is one of my favorite copper peptide options. It really does add multiple levels of hydration to the skin because of its lipid formula and the technology they use in this actually means that the majority of those copper peptides get to where they need to be in order to deliver the results. We often have a lot of copper peptide wastage because not all of them will actually get to where they need to be in order to work."
~Yay
"Niod kale serum love it"
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"I really hated this at first and my skin freaked out from it and broke out a little bit, and I'm not sure exactly what changed, but when they had their sale I bought two of them and I recently just finished one up and I really enjoy it now. I use it a little bit differently than I did the first time. Now I use it as the very last step of my evening routine on my face and neck, and whenever I used it before my skin would freak out and break out from it, and now I don't have those same issues."
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"It hates it. I repurchased it, thought I'd give it another try during the NIOD sale, and same thing. The first time I tried it was a couple years ago, maybe things have changed, maybe it was a fluke, but I tried it again and same thing. So I tried it twice, I'm not trying a third time, because now I know it just doesn't agree with my skin. Something about the formula does not agree with my skin. There's only one other real product that ever breaks me out, and that is 100% pure squalane oil."
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"The NIOD Copper Amino Isolate Lipid is lovely, it's got squalane in there, blue-green algae. It's really nice, it's expensive though. I didn't realize it had crept up to $93 when I reviewed it initially. I believe it was $73 four years ago, so obviously the price has crept up since then. [...] It's expensive, although a little bit of it goes a long way. It's the half an ounce size, [...] so if you're on a budget, that's not going to be the most friendly one."
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"This is probably my fourth tube of this. The first couple tubes I used I didn't love it. The second tube it took me like months to finish it and then they had it on sale last year so I picked up a couple more tubes and it really worked even better. I don't know why the first couple tubes of it I didn't love. I think it maybe my skin a little bit congested and things like that but the last couple tubes of it I love it, definitely repurchase it."
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"This also uses 1% copper peptides in a squalane base. It is in a very hydrating gel formula, and for very acne-prone skin I would not recommend this, but if you have dry skin or oily skin that's not acne-prone, give it a whirl. It is very hydrating, but for some people with acne-prone skin they don't have the best luck with this."
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"At first I hated this product. [...] The first tube of this I hated and then it was on sale so I repurchased it and I found I actually liked it. [...] The first time I used it just seemed to really suffocate and clog my pores and this time I didn't have that same experience. So I guess if you have oily or acne prone skin it might be a little touchy. I'd probably go with a serum texture. Although this does use an encapsulated copper peptide, [...] copper is my favorite part here."
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"I've got the NIOD Copper Amino Isolate Lipid 1%, which the first tube I used of it I really didn't like too much. I wasn't going to repurchase it. However, during a sale it was a really really good deal, I think it was half off, I think it was last Black Friday sale, so I picked it up and actually I ended up really enjoying it. So I've repurchased it now since then. It's 93 bucks, kind of expensive."
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"But copper peptides are wonderful for anti-aging. Just be cautious how you use them. You don't want to use them with a lot of actives, especially ones that have a low pH, because it can break up the peptide bond. So you don't want to use it with glycolic acid or certain exfoliants, lactic acid, things like that. Or if you do, be sure to use a neutralized product in between them so that the copper peptides can do their job without being disturbed by the low pH of actives."
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"The formula is great, it just feels slimy and greasy and it feels like it sits on top of my face. [...] I didn't finish it right away because it was greasy and I broke off from it, so I let it sit for a couple months and then I went to finish it. [...] The product had disintegrated basically, so all this oil came out. [...] It just didn't sit well and it disintegrated pretty fast."
~Nay
"I received the NIOD copper amino isolate lipid one percent, a copper peptide product that's more of an oily [...] moisturizer rather than a cream. It's great if you have dry skin, unlike their serum which is too watery and lightweight to really help with dryness. That said, [...] I wouldn't buy this again, I didn't hate it or anything, I finished it, but I wouldn't buy this or their serum again. I still like Peach and Lily's copper peptide serum the most."
~Mixed
"The Copper Amino Isolate Lipid is very similar to the serum except for this one has that thick texture. Depending on what type of texture you are looking for, that will determine which one to go with. I always chose the serum because it's easier to use, it's thin, it's lightweight, it layers up nicely with skincare, and I've never had an issue with peeling."
All 3 takes from Sincerely Miss Ash
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"I do feel like this performs better than The Ordinary copper peptide because the ingredients are more advanced. I just feel like this one works a little quicker from the experience that I have had with the two. I really do like this option especially if I'm looking for something that is a little bit more moisturizing that has that plumpy effect and I really like the way that this applies to the skin."
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"The Copper Amino Isolate Lipid is very similar to the serum except for this one has that thick texture. Depending on what type of texture you are looking for, that will determine which one to go with. I always chose the serum because it's easier to use, it's thin, it's lightweight, it layers up nicely with skincare, and I've never had an issue with peeling."
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"I picked up the Copper Amino Isolate Lipid, which is pretty much the exact same as this but in that bomb type of texture. [...] I'm really curious to see how this is going to work because it's been a while since I've used this and I can't remember how I liked it. I can't remember if it pilled, how it layered out with my skin care."
~Yay
"CAIL is a bit more of an acquired taste in my opinion, I personally love it though. This formula is all about volume and keeping that youthful, plump volume. It's mainly the texture that I believe is not for everyone. It might put some people off, but I think [...] you have to play around with this first when you first try it. It's gonna seem like it can't really spread, it's gonna seem too thick, almost Vaseline-like, but it goes through a texture change while you're applying."
~Mixed
"I've been using it now for two weeks just at night over my treatment, as like the last step. It's really oily when I wake up the next morning. I have not seen any dramatic change. My skin is moisturized, fine lines are smoothed down, but I'm not seeing like a major transformation. The overall texture, consistency, formulation, the delivery system, I'd like to see some more brands dipping into this shape because I really like it. It's almost like it wants to be an oil. It's like a gel oil."
Sponsored
All 3 takes from Dr Dray
I About Lost It Over This
"I've been testing out the NIOD Copper Amino Isolate Lipid 1%. I've tried their copper peptides in the past but this I feel like I've tried it in the past too. I like it, it's oily, it's shiny. But this new packaging they need to rework this. I barely had it for a week now of use and the label is peeling right off. I understand why they do that but it's like come on guys, get it together with whatever adhesive you have on there. It needs to adhere, it's not adhering."
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"I really like this. [...] I tried not using it a couple of times to see if there was any sort of more immediate visible difference in my skin. [...] When this is on in the nighttime routine, the following morning it's like, oh, this looks good. The skin is looking good. I attribute it really just to the vehicle here, not necessarily the ingredients, [...] but I do see a visible morning after difference in terms of how good my skin looks just from an aesthetic perspective."
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"I've been using it now for two weeks just at night over my treatment, as like the last step. It's really oily when I wake up the next morning. I have not seen any dramatic change. My skin is moisturized, fine lines are smoothed down, but I'm not seeing like a major transformation. The overall texture, consistency, formulation, the delivery system, I'd like to see some more brands dipping into this shape because I really like it. It's almost like it wants to be an oil. It's like a gel oil."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is NIOD Copper Amino Isolate Lipid 1%?

A copper peptide product with a rich, lipid-based oil texture, designed to hydrate skin and support a plumper, more youthful look.

Is NIOD Copper Amino Isolate Lipid 1% worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 69%.

What is NIOD Copper Amino Isolate Lipid 1%'s Guru Score?

NIOD Copper Amino Isolate Lipid 1% holds a Guru Score of 69%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected.

Who is NIOD Copper Amino Isolate Lipid 1% best for?

NIOD Copper Amino Isolate Lipid 1% is generally suited to dry skin and mature skin.

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