Is NIOD Copper Amino Isolate Serum 2:1 worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 73%.

What is NIOD Copper Amino Isolate Serum 2:1's Guru Score?

NIOD Copper Amino Isolate Serum 2:1 holds a Guru Score of 73%. That is our read on how warmly the experts talk about it, based on the verdicts of 9 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

Who is NIOD Copper Amino Isolate Serum 2:1 best for?

NIOD Copper Amino Isolate Serum 2:1 is generally suited to mature skin.

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NIOD Copper Amino Isolate Serum 2:1.

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Serums

About this product

A lightweight copper peptide serum designed to support skin firmness, collagen production, and the appearance of fine lines.

Guru Score

73%

Mixed

9 experts · Strong agreement

What the gurus are saying

This watery copper peptide serum earns consistent praise for its thin, non-sticky texture and ability to firm skin and soften fine lines, though experts split on whether the premium price justifies the results. The texture is its calling card (light and water-like compared to heavier alternatives) making it easy to layer into any routine. However, those with dry skin may find it too lightweight to deliver noticeable hydration on its own, and several gurus note that copper peptides are no longer rare enough to command the high cost. Best used on non-retinoid nights and avoided alongside strong actives like retinol or acids.

Synthesized from 9 expert reviews · most recent take August 2026

What they liked

Lightweight, watery texture
Works well with non-retinoid routines
Firming and rejuvenating effects

What they flagged

Too thin for dry skin
Expensive compared to alternatives

Best for

Mature skin

Type

SerumsDrops & dropper

Where to buy

Sephora → Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Sincerely Miss Ash

195k subs

~Yay

"The NIOD Copper Amino Isolate is amazing, I love this product a lot. Copper peptides stimulate collagen and firm the skin, and help address fine lines and premature signs of aging. [...] I've been using copper peptides for several years now [...] and it's all I use now because it really does perform, and I refuse to remove it from my routine."

Top Pick: copper peptide serum

All 13 takes from Sincerely Miss Ash

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"This is a copper peptide serum that I talk about all the time here on my channel and it's one of the best in my opinion. I do like to occasionally use this in my morning routine and sometimes at night time and I do like to alternate between this and other copper peptide serums as well."

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"This is honestly one of the best copper peptide serums I have ever used. [...] I really love this one because it is more advanced. I see quicker results with this serum. And this serum truly performs in terms of firming and just giving more of that rejuvenated youthful appearance to the skin. Copper peptides can also help to stimulate new collagen and softens fine lines and wrinkles and a great preventative serum as well. Now, this isn't a cheap serum. This is quite pricey."

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"I do have an empty NIOD Copper Amino Isolate Serum 2:1, this is the little 15 mil size. This is their copper peptide version which is very similar to The Ordinary one but I do feel like this one works a little bit better. The texture of this is like water whereas The Ordinary is more of that jelly type of texture, that gel. So it just depends on what preference you like in terms of texture and price point. This one is more money than The Ordinary but it's amazing and fabulous."

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"I also quite enjoy the NIOD Copper Amino Isolate Serum 2:1. Like, there's a lot that I do like."

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"NIOD also has one, it's the Copper Amino Isolate Serum, that one is very similar to The Ordinary, a little bit different in terms of ingredients and texture. I love that one as well but this one is a little bit more affordable."

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"I also love the NIOD Copper Amino Isolate Serum 2:1."

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"This is one of my favorite copper peptide serums, and this really performs. This firms the skin. It helps to stimulate collagen and it also helps to target fine lines and wrinkles. A very hydrating formula as well. It's very thin like water. It has a dark blue hue to it. And this is something that can be used in your morning as well as your evening skincare routine."

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"It dries down skin-like. There's no glow to your skin, and it's not sticky or tacky. It never pills with skincare, at least from my experience with this. And this can be used every day, twice a day. When I use this, I don't pair this up with other active ingredients like retinol, [tretinoin]. I don't pair this up with any type of exfoliating acid or ascorbic acid, vitamin C. You can use vitamin C derivatives with this. You can use growth factors with this. Niacinamide, hyaluronic acid."

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"The one from The Ordinary I do feel like is a little bit more moisturizing on the skin but they both spread nicely across the skin. There's no paling whatsoever and I do feel like the NIOD one works a little bit quicker from the experience that I have had with the two but you can't go wrong with either one. So yes I will be continuing on with this for sure."

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"The ingredient list here is very impressive and I haven't found anything that is similar to this yet. I haven't found a dupe to this yet, so this truly is one of a kind in my opinion and it really is effective. It has a thinner texture, it's almost like water, but the formulation itself is more advanced."

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"This serum with that copper ingredient, I do feel like this one performs better. I achieved quicker results with this serum over the ordinary one, but of course we're all different and you can't go wrong with either one, they are both fabulous. So I'm going to rate this serum a 10 out of 10."

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"Although I have a lot of favorites when it comes to copper peptides, this is my top pick, the one I've been using the longest and will always continue to use. It is truly 10 out of 10, this performs really well. [...] I love how thin and lightweight it is, it's truly like water. Copper peptides help stimulate collagen, firm the skin and soften fine lines, [...] and I think this one from NIOD is one of the most advanced formulations I've ever used."

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Dr. Mamina

282k subs

~Yay

"The NIOD copper peptide products are ones I really like for incorporating copper peptides."

No BS Beauty

89k subs

~Yay

"Their node copper serum is nice. It's super light, watery texture. So if for some reason their lipid serum is too heavy or you don't like the ordinary one, this one's nice. It's watery, so you can just add it into your routine pretty easily without having to change anything else. It's just super waterlike texture. So if you think the other one's too heavy, this one's nice. But it's expensive."

Dr Dray

2.69M subs

~Mixed

"It's not a holy grail mustave but yeah if you don't know the backstory you need to watch the backstory"

AliceintheRabbitHole

59k subs

~Nay

"NIOD's copper peptide serum is extremely watery, too lightweight to really help you out if you have dry skin. I wouldn't buy this or their other copper peptide product again."

Mad About Skin

731k subs

~Mixed

"The NIOD copper peptides are nice but too expensive. Copper peptides used to be unique and commanded a higher price point, but they do not anymore and do not need to."

Doctor Anne

56k subs

~Yay

"On the non-retinoid nights I go in with the NIOD Copper Amino Isolate Serum 2:1. This is one of the more expensive versions, The Ordinary has a more affordable one, but I much prefer this texture, which is light, watery and not as oily as the other ones."

Beyond50Skin

32k subs

~Mixed

"I picked up the copper amino peptides. I've been trying copper peptides this year to see if I'm missing the boat on copper peptides and see how they respond on my mature skin. In the past I haven't thought they've worked but I'm game for trying them again. This was in my evening routine to kind of help with the hydration."

Cassandra Bankson

2.46M subs

~Yay

"The copper peptides from NIOD are so fun. You get to mix them and activate them together. You should use them within 30 to 60 days, so if I'm buying this, if I'm mixing it end of November, I'm probably going to use it during December."