Superoxide dismutase, the antioxidant in this mist, is what most of the praise centers on, with several noting it hydrates and helps ease the look of redness. The sprayer splits the gurus, since some find it hard to mist evenly while others call the pump great. Some who struggle with the spray apply it with their hands first and use it like a toner, and the scent is not to everyone's liking.
Synthesized from 6 expert reviews · most recent take July 2026
"This is the third generation mist. If you have accelerated signs of aging or spend a lot of time outside, I'd use this one every day, at least in the morning, and [...] use the second generation mist at night, though you can use both every day twice a day. I think I'll be using this one more in the summer months since I'll be outside more. It hydrates and is [...] great for signs of aging, used after cleansing but before serums. [...] I love both and have backups of both."
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"I have seen great results with this facial mist in particular and I feel like it's one of the best on the market. There's a lot of facial mist that will just hydrate your skin, but this one does more than just that. [...] This has a lot of antioxidants in it and antioxidants protect the skin. It's also going to be brightening, something that's going to hydrate and also reduce the look of facial redness. This is also going to be a great anti-aging serum to prevent fine lines."
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"I am super consistent with the NIOD Superoxide Dismutase facial mist."
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"You guys know how much I love this. I've been using this for so many years and I use it every day twice a day. This is truly one of the nicest facial mist I've ever used because there's a lot of antioxidants in it to help protect and shield your skin from pollution. This is great to use in your morning, but also there's ingredients in here to help reduce the look of facial redness and this really does help to reduce on that rosiness. It hydrates the skin, it preps your skin for your serums."
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"I do really like this a lot. This is great for all year round, but especially come summer because I'm going to be outside a lot more, I'll probably gravitate towards this one a lot more, like late spring into early fall. This is also going to prep your skin for your serums. It also hydrates the skin. There's a lot of ingredients in here to target and prevent signs of aging. And yes, it can help to reduce the look of facial redness as well."
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"This is the second generation. [...] I really like this one. [...] It's hydrating and there's a lot of antioxidants in it that will actually help to calm any redness, but also it just preps the skin for your serums. And [...] it's very advanced. Like prior to the enzyme third generation, there's nothing like this on the market. NIOD really has some impressive formulations that you will not find anywhere else. The ingredients that they use are very advanced and this is truly 10 out of 10."
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"This is hydrating. It's a great product to use after cleansing, but before your serums and moisturizer. This is also another product that you could spray on top of your face throughout the day as well as a refresher and also to add more protection to the skin. It can help to reduce the look of facial redness. I really do like it and I did purchase a larger size during that Svember sale. I really think that this is a great option for protecting the skin and for signs of aging as well."
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"I absolutely love it. I did purchase this with my own money the day of the launch, which I believe was back in September, and I've been using it every day, twice a day since I received it, and I love it. [...] This is more advanced than the second generation. It has different types of antioxidants that are newer, a newer technology of antioxidants that really target accelerated signs of aging. It has more of that aggressive approach to protect our skin from pollution."
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"This is the NIOD Superoxide Dismutase Saccharide Mist, the facial mist that I use every day twice a day. You guys know how much I love this. It's great to hydrate the skin, great to reduce redness, but also there's a lot of antioxidants in here that can benefit the skin for signs of aging as well. This is just one of the best that I have ever used."
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"Honestly, this is one of the best anti-aging facial mists I have ever used, mostly to protect the skin from everyday stressors because this is full of different types of antioxidants. This pairs up nicely with vitamin C serums and I also use this with copper peptides. I honestly pair this up with everything, even [tretinoin], even lactic acid. [...] This is also a product that helps to reduce the look of facial redness, and I do have a little bit of rosiness to my skin naturally."
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"I use every day twice a day so this is a facial mist that is very friendly with other ingredients you can use this with vitamin C, retinol, copper peptides, niacinamide, you can use this with everything and this is an antioxidant facial mist that can help to address fine lines and wrinkles it can brighten up the skin it protects your skin from everyday pollution so I do love this more so in the morning because it does help to protect the skin from everyday stressors and this is also a facial mist that can help to reduce facial redness whether you have that natural flush to your skin maybe your skin is a little rosy because it's irritated or maybe you've had some blemishes and of course when you do have a blemish redness can occur so this can help to reduce on rosiness especially when you are consistent with it and I like using this right after cleansing but before my serums and my moisturizer and again this can be used every day twice a day and this does tend to sell out from what I have seen in past years so I will be picking up a few of these but if you love this as well or you've never tried it I really do recommend it stock up because I'm telling you it is that good"
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"I use this pretty much every day twice a day and I've been doing that for a really long time. This is a facial mist that truly does it all. It has antioxidants in it that can help to address signs of aging, but antioxidants protect our skin from everyday pollution. If you want to use this with another type of antioxidant serum or your vitamin C serum you could totally do that, and then all of those antioxidants can really help to protect your skin from everyday stressors."
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"This is a great mist to hydrate but also to reduce redness of the skin, but this has a lot of antioxidants so this is also great for signs of aging and it can help protect your skin from everyday pollution. Great for your morning routine, great for your evening. I do like to put this onto damp skin as well."
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"The Neostrata Superoxide Dismutase Saccharide Mist is what I use every day twice a day as that product before my serums. I feel like this preps my skin for my serums for better absorption, but also this is full of antioxidants so this is going to protect your skin from environmental stressors which is everyday pollution. This can also help to hydrate the skin, reduce redness, and perfect for signs of aging. This really does help to reduce redness but it just keeps your skin looking so amazing."
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"This is the third generation of this one, and this is a new launch. [...] I picked up a 50 mil size because I wasn't sure if it was something that I was going to enjoy, but I actually really love this. [...] There's [...] a newer technology of antioxidants in this one. This one is more aggressive to protect our skin from pollution, collagen banking, keeping that collagen in our skin, but also it does help to reduce the look of facial redness. It does target fine lines and wrinkles."
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"The new enzyme mist is even more advanced and more aggressive to protect the skin from everyday [...] pollution. It has new antioxidant technologies that really help to keep the collagen and elastin that we currently have and from getting worse. [...] The superoxide dismutase in it is something our body naturally has as its way of protecting our skin from pollution, and as we age, that natural superoxide dismutase degrades."
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"I finished the NIOD Superoxide Dismutase Saccharide Mist. I always need to have backups of this in my linen closet because I use this everyday twice a day. It's a great hydrating mist but also it helps to reduce facial redness. There's a lot of antioxidants in here to protect the skin from everyday pollution. It can help to brighten the skin and it's great for signs of aging. So I really love this and yes I am going to be continuing with it for sure."
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"I love my facial mist and I feel like this pairs up nicely because this is also full of antioxidants so this is going to also protect your skin from everyday pollution. It's going to give you a brighter complexion as well. It hydrates the skin but also this formula can help to reduce redness as well. I love it and I use this every day twice a day and I've been using this for a really long time."
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"It is jam-packed with several antioxidants. This is honestly unique. This is very advanced and I haven't found anything like this yet. There is no dupe to this yet. [...] It helps to really protect your skin from environmental pollution. It helps to reduce the look of facial redness. It hydrates and it preps your skin for your serums and moisturizer. And there's a lot of other anti-aging ingredients in here to fight signs of aging. So it really is a nice one to use every day."
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"You guys know that I absolutely love this and I use it twice a day. I've been using this for several years and honestly I can't recommend it enough and I can't stop using it. It's just so hydrating but also it's a fabulous product to tone down on facial redness. But it also has a lot of antioxidants in it as well to help protect your skin from the environment but also to treat early signs of aging."
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"I use this every day twice a day and I have been for a very long time. [...] This is amazing, I haven't found anything like it, there is no dupe to this product out there as of yet. This is very effective to hydrate the skin, to prep your skin for your serums and your moisturizer, but also it's full of antioxidants so great for signs of aging, great to protect our skin from everyday pollution. If you're someone that has redness, this can really help to reduce on rosiness."
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"You know how much I love this, especially if you've been with me for a while. It's my go-to facial mist that I use every day, twice a day, and I do use this all year round. This is extremely hydrating. It also helps to reduce the redness of the skin. It's full of antioxidants so it will help to protect your skin from pollution but also to address signs of aging. I haven't found anything like it, so until I find a dupe, this is what I'm using every day. It is a must."
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"The NIOD Superoxide Dismutase Saccharide Mist is full of antioxidants and I've been using this for many years now and I use it twice a day and I really love it. This really does help to reduce redness, it hydrates it, preps your skin for your serums and moisturizers, but also it can help to protect your skin from everyday pollution and also target signs of aging and it can help to brighten up your skin."
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"Honestly, I couldn't tell you how long I've been using this product, it's been several years and this still never disappoints. I just love how this decreases the redness on my facial skin. It is also very hydrating. It has a ton of different types of antioxidants to help with signs of aging but of course to help protect your skin from everyday stressors. So this is something that I use every day, twice a day, and I have been for several years."
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"This has a lot of antioxidants in it so it's going to protect your skin from free radicals. I do like to use this with my vitamin C and then of course this is that additional product with antioxidants to protect my skin from the environment. This is 10 out of 10."
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"I've been using this Mist for the last couple of years and I'm so impressed with it. It's great for hydration, great for anti-aging, great to help reduce rosiness, and it really is a lovely product to protect our skin from everyday pollution because antioxidants can really help to protect our skin from free radicals. [...] One bottle will probably last me 2 months, maybe just over two months. [...] It lasts way longer than a month."
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"This is the third generation mist. If you have accelerated signs of aging or spend a lot of time outside, I'd use this one every day, at least in the morning, and [...] use the second generation mist at night, though you can use both every day twice a day. I think I'll be using this one more in the summer months since I'll be outside more. It hydrates and is [...] great for signs of aging, used after cleansing but before serums. [...] I love both and have backups of both."
"I liked the version 2 much better than this one. This stuff was terrible, really hard to mist it evenly. The previous version you could mist and be very even to the point where you could apply it over makeup. I just apply this like midday as I'm going through the day for some hydration boost and things like that, but yeah, the nozzle, the sprayer on this was awful. And it did have a scent. It wasn't a fragrance ingredient, but it had a strong scent from one of the ingredients."
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"I liked the version 2 much better than this one. This stuff was terrible, really hard to mist it evenly. The previous version you could mist and be very even to the point where you could apply it over makeup. I just apply this like midday as I'm going through the day for some hydration boost and things like that, but yeah, the nozzle, the sprayer on this was awful. And it did have a scent. It wasn't a fragrance ingredient, but it had a strong scent from one of the ingredients."
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"I'm not loving that. [...] It's like a Nerf super soaker gun. It has just a little bit of an acidic smell and then it goes away. [...] They changed their formula for their superoxide dismutase. It contains the newest form of SOD, which is [...] SOD 3, extracellular superoxide dismutase. It's a form that lives outside cells and is supposed to be stronger than their [...] other versions. Superoxide dismutase neutralizes free radical damage, so pollution."
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"However, the nozzle on this is terrible. It's awful. I don't know why they picked this nozzle, especially if they're working on it for 3 years. The nozzle is a main issue of this. It's not up to the quality of the old nozzle. A lot of other products that are much more affordable have a much better nozzle as well. [...] There's no denatured drying types of alcohol. There's no fragrance ingredients, but this does have a distinct scent and it's not a pleasant scent, I would say."
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"For 40 bucks, the Superoxide Dismutase Mist I love this mist, it's super nice, it's got super fine particles on it. I use it over and under makeup, so it's great for protecting your skin from free radical damage, pollution, and environmental stressors. In here we've got malachite extract which is made from a specific stone and they shave it down and it's great for antioxidant protection."
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"I love this stuff. I use this every single day. It's wonderful. I use this for protection against free radicals, protection from pollution, and just overall skin health and hydration. I love this stuff. My backup's already arrived and already in place and already been using it."
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"I love that stuff, it's amazing. I use it every day, love it."
"Neod do this, which is a super oxide dismutase mist. This is a mist that you spritz on after cleansing, lock in all that antioxidant protection. [...] These are like next level antioxidants that work so well alongside your sunscreen for just protecting your skin no matter what the world throws at it."
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"Neod do this, which is a super oxide dismutase mist. This is a mist that you spritz on after cleansing, lock in all that antioxidant protection. [...] These are like next level antioxidants that work so well alongside your sunscreen for just protecting your skin no matter what the world throws at it."
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"The pump on this is great and it's packed full of antioxidants. So this is like your toner, your mist, your antioxidant all in one. A great way of streamlining if you're someone that likes to have a mist or a toner but you also want to have an antioxidant alongside it. This is like a two-in-one. It is absolutely great, feels great on the skin, and yeah, I feel it just helps to get that hydration going early on."
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"This is an antioxidant. It's a beautiful refreshing mist. It's a great way to start your skincare routine because I like all my skin care to go on to damp skin because I feel it absorbs better and that is a great way of just refreshing the skin."
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"This is the NIOD Superoxide Dismutase Saccharide Mist. It doubles up as your mist and your antioxidant all in one, so it's amazing, absolutely amazing if you're looking for streamlining and just a little extra hydration. [...] It feels great and wakes up the skin."
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"The NIOD Superoxide Dismutase Saccharide Mist is a really great mist if you want a mist in your skincare routine, but one that's packed full of calming, soothing, and antioxidant properties. This mist is amazing. Sprits then apply the rest of your serums while it's still damp and you'll just take any of the other NIOD products to the next level."
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"This is hands down the best mist in the skincare world. It's an antioxidant mist but it also deeply nourishes and hydrates. It has one of the best pumps I think I've ever seen on a product, just dispenses the right amount in a beautiful light mist. One of these which I use in the morning will last me two months, maybe two and a half months."
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"For me, it's definitely a different product. I love this. Always stocked up in the sale. One of my favorite products. It's like times two greater antioxidant protection. I think it's got a broader range of antioxidants and the fact that it works on contact just means that we can spritz, protect, and go. And I'm all for that. Just make sure you use it alongside your sunscreen to maximize on that protection. Antioxidants don't replace sunscreen. [...] They work well together."
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"This one is great for just all round antioxidant power. Both are great. It [...] fundamentally does the same thing: protect the skin, hydrate the skin, and ward off free radical damage."
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"It's a really nice option for a little specific antioxidant treatment in a mist. If you already have enough serums and enough creams, and you want something a bit different, mix up those textures. This is a really nice mist that you can just spritz onto the skin. Keep it in the fridge, and it's instantly calming, soothing, and cooling, and it gives you that burst of antioxidant protection. This would go earlier in your skincare routine because it's a mist."
"This is the NIOD Superoxide Dismutase Saccharide Mist, one of the best antioxidants out there. Great for people that like their antioxidant in a mist. If you want to use this as a hydrating toner and antioxidant in one, this is a great option to go for. It's been one of my favorites and I always put a couple of these on order during the NIOD sale in November. [...] I love this. Quick spritz is all you need for the antioxidant protection."
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"It also has a beautiful pump on it. I cannot recommend this enough. In fact, this is the sort of thing I never throw a bottle of when I'm done, I rinse it through and then I'll put other toners in it because I just think this is the best bottle and pump I've ever found on a mist. [...] It's also one of the cheaper NIOD products, which is always good since NIOD does have a slightly higher price point than a lot of their competitors, but it's worth it for the formulations."
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"I love their Superoxide Dismutase Mist which is a great antioxidant mist for a little hydration too."
"My one complaint, which I feel is a significant oversight, is the misting function of this is abysmal. I mean, this is beyond tolerably bad. It's like I can't use it by misting it on my face because it comes out in one incredibly strong and focused stream. So, the way I apply this, and this is the best way to do it, I apply on my hands first and just use it like I would a regular hydrating toner or essence. This has a real fast impact I find on redness, especially the winter cold redness."
"My repeat purchases are the fractionated eye Contour concentrate as well as the super oxide dismutase saccharide Mist, both of which I use every day."
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"This is an antioxidant spray that I have been using for years. It comes in a huge bottle which makes it a pretty good value for money. This has always been one of my dupe products that I automatically repurchase, but I didn't this time and that's only because I've been using another product instead. But will I go back to this in the future? Absolutely."
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"My repeat purchases are the fractionated eye Contour concentrate as well as the super oxide dismutase saccharide Mist, both of which I use every day."
"I just sprayed this in my eye, this is the superoxide dismutase from NIOD. I call it like the big sister to the Ordinary, it's like the grown-up older PhD sister because of how much tech goes into these skincare products. I absolutely just sprayed this antioxidant spray right into my eyeball."
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"I just sprayed this in my eye, this is the superoxide dismutase from NIOD. I call it like the big sister to the Ordinary, it's like the grown-up older PhD sister because of how much tech goes into these skincare products. I absolutely just sprayed this antioxidant spray right into my eyeball."
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"I've actually been introducing NIOD into the practice. NIOD is like the ordinary's big sister, it's like an elevated PhD form of the ordinary. This right here, the superoxide dismutase, this is such a great spray for skin very different from someone who has acne where I would use the other product. Whereas somebody who is coming in for a day treatment or day procedure, maybe they've had like medical microneedling in the past and they need more skin support, this is absolutely what I'm going for."
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"So theoretically if we apply superoxide dismutase topically to the skin, that might help. Again, is it going to cure it? Absolutely not. But can it hurt? Probably not. And if you really like the spray form of this or if you have rosacea and this is something that you're willing to give a try, I've heard and seen anecdotally this antioxidant does great things and I personally love it."
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"NIOD Super Oxide Dismutase, oh my god, this mist is amazing. Talk about antioxidants that you might want to apply underneath a sunscreen—this is it. This purple little bottle has superoxide dismutase, such an amazing antioxidant. Although it's not the same as sunscreen, there are some studies that are looking at its potential to boost up a sunscreen or to help with UV damage from the sun."
What the evidence says.
Independent of what the gurus think, this is what
the published research supports about the main active ingredients here.
Frequently asked.
What is NIOD Superoxide Dismutase Saccharide Mist?
A facial mist built around superoxide dismutase, an antioxidant, designed to be spritzed over the skin for antioxidant protection and hydration.
Is NIOD Superoxide Dismutase Saccharide Mist worth it?
Mostly yes. 4 of the 6 gurus who reviewed it give it their stamp of approval, for a Guru Score of 82%.
What is NIOD Superoxide Dismutase Saccharide Mist's Guru Score?
NIOD Superoxide Dismutase Saccharide Mist holds a Guru Score of 82%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.
Cheaper alternatives the gurus rate.
Lower-priced mists and essences the gurus still rate highly, versus this mid-range pick.