What is OneSkin OS-01 Body Topical Supplement?

A peptide-based topical body treatment from OneSkin, aimed at crepey skin and the look of aging skin, with a light, serum-like texture.

Is OneSkin OS-01 Body Topical Supplement worth it?

Yes. All 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 89%.

What is OneSkin OS-01 Body Topical Supplement's Guru Score?

OneSkin OS-01 Body Topical Supplement holds a Guru Score of 89%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

Who is OneSkin OS-01 Body Topical Supplement best for?

OneSkin OS-01 Body Topical Supplement is generally suited to mature skin.

OneSkin OS-01 Body Topical Supplement: a Guru Score of 89%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Beyond50Skin

32k subs

✓Yay

"I did not expect this at 60, but it actually helped get rid of the [...] crepey skin, especially over my knees. To make it last longer because it's so pricey, I put a layer of Hydro Boost on first so my [...] skin is already moisturized, which helps it glide on better and lets my skin accept all the peptides in it. It has [...] a proprietary peptide that helps with senescent cells. [...] Pretty cool product, pretty expensive product, but awesome."

Top Pick: crepey skin treatment

All 11 takes from Beyond50Skin

OVER 50 SKINCARE EMPTIES: My Biggest DISAPPOINTMENTS & Instant Repurchases

"I keep this in my bathroom all the time. And I layer it up with my OneSkin for the body with the OS-01 peptides for that help with senescent cells. [...] I can't give it up. And [...] honestly I haven't found anything that works better. You can combine this peptide formula with retinol, though you don't want to combine your body exfoliation night with your retinol, but you can combine it with the OS-01 for body. These are both already repurchased. They are sitting downstairs in my bathroom."

WINTER SKIN SURVIVAL KIT ❄️ Stop Trans-Epidermal Water Loss (TEWL) for Mature Skin Over 50 Skincare

"The peptides in this and the skin rejuvenating benefits that I've seen from this are just like no other body lotion I've ever used. I honestly can't skip this in my body care routine."

Life Over 50 | Everyday Makeup, Town Walk & Mouth Taping for Better Sleep?

"Is it expensive? Yes, it's expensive. But does it work on cranky skin? Yes, it does. It's kind of more of a serum like texture as opposed to a lotion. I guess if you don't have very dry skin, you might consider it like a light lotion, but it definitely isn't the only moisturizer I need for the body. I love this. I am going to have this on repeat as much as I can afford it. I love it over my crepey knees. I love it for my crepey underarms. You can use it in kind of targeted spots."

WINTER SKINCARE PLAN: Get the Best Skin of Your Life Over 50

"I've been using the OneSkin OS-01 Body Topical Supplement. I gave you a full detailed report in my fall skincare check-in and I love this. It had some amazing differences on the crepy skin on my upper legs."

Did My Fall Skincare Routine Work? Best Skin of Your Life Check-In

"I've been using their body formula and [...] I was pretty surprised especially about the creepy skin over my legs. I only used the OneSkin OS-01 Body Topical Supplement over my knees the last eight weeks no other body products. [...] I just went around that area and I also used it on my hands. [...] I really tried to stay away from every other body product and exclusively use the OneSkin Body."

2025 Body Care for Crepey Skin Over 50 | Holy Grails, New Finds & OneSkin Results!

"It's the OneSkin OS-01 Body Topical Supplement. [...] I used this exclusively for 3 months, morning and night, none of my other body skincare, just to see what the results would be. [...] This is full of peptides. Whether you just jumped out of the shower or you're just waking up and getting dressed, the OneSkin body goes first in your body skincare routine. It acts to increase and firm the skin barrier. It has a proprietary peptide. [...] This is a step that we don't skip."

Empties, Fails & Faves LIVE! Over 50 + AMAZON Beauty Prime Day Chat

"This is their body formula that I'm in the middle of. I think they're going to have a deal on this. I just have a feeling this has become so popular."

6 Months of Skincare Empties | My Husband’s 1st Routine in 60 Years + Results

"It's definitely bougie, not inexpensive, but it has transformed the crepey skin of my body. [...] Yes, it's expensive and yes, it's worth it, but you can just use it in targeted areas. [...] I started out just using it over my knees last fall because that was kind of my area of concern, and then this spring I did a trial and used it on my crepey upper arms and my lower legs, but I skipped the torso. So it can be used just in trouble spots."

Black Friday Discounts 2024! BEST FINDS For Mature OVER 50 Skin

"Two new body products I've been trying late this fall are the OneSkin OS-01 body lotion and the Fenty Skin whipped body butter, these in combination are just amazing. The OS-01 peptide in this body lotion penetrates the skin and helps renew it from the inside out. OneSkin is having an amazing bundle deal for only $99."

Top Beauty Picks of 2024 Over 50: Skincare, Makeup & Hair Care

"OneSkin has been the creepy skin savior. If you haven't seen that video I'll link it up above, check it out. If you don't want creepy skin on the body, you have to check this out. Is it frightfully expensive? Yes. Do I wish I probably had never found it? Yes, but it is the number one for creepy skin."

Top 5 Picks: Epic CVS Beauty Sale & Over 50 Chat

Sincerely Miss Ash

195k subs

✓Yay

"It's so moisturizing, it has a few different oils in it but it's not oily, your clothes don't stick to your skin, and it has a beautiful silky satin texture. It really is one of the best body moisturizers I've ever used, especially one geared towards anti-aging and improving skin tone and softness. [...] I know it's not exactly the cheapest body moisturizer out there, but the ingredients are very advanced and I'm very impressed with it."

All 2 takes from Sincerely Miss Ash

THE ULTIMATE ANTI-AGING BODY CARE ROUTINE THAT ACTUALLY WORKS (Best Products for Aging Skin)

"I've just started using the OneSkin Topical Body Supplement [...] maybe two months ago and I am really impressed with how this product performs on my skin. [...] It really improves skin creepiness, so if you have creepiness above your knee or anywhere on your legs or the backs of your arms, this really does work."

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Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Yay

"This is the OneSkin OS-01 peptide, [...] a body cream, and it plays really nicely with all the other peptides, so this is great to put on at night. I like to put this on first, morning and night, because it clears the way for the senescent cells so the other skincare I put on after has more chance to reach the healthy cells."

All 6 takes from Darnell Cox | 50+ Healthy Aging Expert

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"I don't know who else is making it with this particular peptide in it, the OSO1 peptide. [...] This has literally changed my skin. And not just the face one, but the body. [...] This has been a game changer. And in terms of the body one as well, a complete game changer when it comes to treating my body. [...] My OneSkin OS-01 is always like my last thing in terms of the body. For the face, it's always my first thing."

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"For the body, I cover my whole body with this."

Is your skincare stash overflowing with expired serums and half used bottles? 🧴 🚨 You wouldn’t

"I'm obsessed with the body. I'm obsessed with it because I have noticed my skin is a lot less dry. It's a lot more supple. It feels better. It's the best, one of the best moisturizers I think I've ever used. Not because it just slathers an inactive ingredient on top like moisture. Moisture is an inactive ingredient. If you only moisturized your entire life you're missing the opportunity to increase the function of your skin."

Over 30 and ready to master the ultimate skincare routine? 🎙️Join me for an IG Live Show where

"It's like a new age active because it's telling those skin cells to purify. I'm loosening up those bonds between the skin cells. [...] When you're using a retinoid, it's kind of the same thing. You're exfoliating by loosening the bond and really kind of taking off those dead skin cells. Now, I'm using something that's telling my skin cells, hey, those ones that are dying, get rid of them. So, it's kind of a double double whammy. I loved a combination of a retinoid with a peptide."

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Skin Obsessed Mary

33k subs

✓Yay

"One Skin products have been in my routine for ages. Their body product was the one thing that made me believe that topical products can work below the neck. The body supplement actually improved the texture of my skin."

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All 15 takes from Skin Obsessed Mary

I Didn’t Repurchase Most of These

"Because over time, the difference became so obvious. I just started using this here on my upper arms, and I went through multiple bottles, and then I started to see the results. And now, I use it everywhere. This was one of the first products that made me realize body care can actually be functional skin care. It's not just moisturizing, it's not just nice. I mean, actual visible change. OneSkin's whole thing is about targeting senescent cells. These are sometimes called zombie cells."

How I Pack for Sun in My 50s (I Do It Very Differently Now)

"The OneSkin OS-01 Body Topical Supplement only takes minutes every other day, so it's super easy to fit into my routine. It's become a non-negotiable at this point and it's become a part of my daily routine. I'm even bringing a travel size with me because I'm making sure that I'm really looking after my body properly."

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"I always start with my One Skin Body Supplement right out of the shower because this is one of the products that has absolutely proven its place in my routine. I've tested it and it works. It's almost eradicated the crepiness of my skin."

YOUR Favourite Beauty Products of the Year (According to You)

"I used to have this really crepey, wrinkly, middle-aged arm skin right here. And it really bummed me out. I started using this product and I only started using it on my arms. I isolated it and I didn't use anything else because there was no way to find out if I used anything else. And honestly it blew my mind. I didn't change my diet. I didn't change my exercise, which was really quite minimal at the time. And I started to see a real change in the skin, and I've been hooked ever since."

The 25 Best Beauty Products of 2025 (That Truly Deliver)

"Their OS1 peptide neutralizes senescent cells. Those are the zombie cells which destroy the healthy skin cells around it. It's like that one bad raspberry in the basket. But here is the thing. This product eliminated my middle-aged, crepey arm skin. Like, I couldn't believe it. So, I did a whole video about this, which I'll list below in the description bar if you want to check it out. I will never stop using this, and it's probably in my top pick of the year."

Skincare I’d Spend My Money On AGAIN (30 Mini Reviews)

"One Skin OS1 body supplement. This is the holy grail body lotion that completely eliminated my crepey skin. I will not be without it. And in fact, I have two empties here. It is pricey, but I keep"

I Asked Skincare Brands for Discount Codes (Black Friday)

"Now, I use all of their products, but if I have to choose two, I would start with number one is the body supplement because it literally got rid of my crepey arm skin. No lie."

⭐️ Products I Can’t Stop Rebuying

"It's the OneSkin body supplement. I've talked about it a lot. It contains their OS1 peptide that helps reduce senescent cells, zombie cells, one of the root causes of aging. This product completely eradicated the crepey, wrinkly skin on my arms. [...] It's really incredible and it has a permanent spot in my routine for hands."

❤️ My Beauty Empties | Here's What Made the Cut!

"This has become my holy grail body product. It contains that same OS1 peptide and I can honestly tell you my crepey skin is now gone because of it. I did an isolated test for about 6 months and I was shocked by the results. So yes, I have repurchased."

🛍️ From PR to Impulse Buys — ALL the Goodies!

"I use each of these products every single day. I mean, this makes me so happy to get this in PR."

❤️ Beauty Empties | Will I Repurchase or Not?

"I'm on my first bottle of the body lotion supplement and I can tell you it has smoothed out the skin on my arms. I think it's kind of amazing. So I may be signing up for the subscription service for that product."

⭐️ Title

"This peptide helps to reduce those senescent cells but it also helps younger cells to multiply and that's what helps to build collagen to strengthen our barrier and just improve overall skin health. [...] I got their bundle which has the face supplement which I use as a serum, the eye cream as well as the body lotion. I haven't really been using these long enough to truly give my feedback but anecdotally I believe I'm actually seeing a difference particularly on the creepy skin of my arms."

✨ OneSkin Review | OS-01 Peptide That Changed My Routine ✨

"There is one skincare brand I'm actually afraid to stop using because the results were that good. I'm talking about One Skin and especially their OS-01 peptide. [...] Very occasionally there are some that truly stand out. One Skin is one of them. I started with their body lotion, and honestly, I just didn't expect much. But three months later, this horrible, crepey, wrinkly skin was disappearing. I mean, completely disappearing. So I had to ask, what's in here that's making such a difference?"

I Can't Buy American Products Anymore

"I've been using OneSkin's body supplement religiously for years. This is the product that completely changed my middle-aged skin, especially the crepey grossness I had, [...] it is the only thing that has worked. But with the new import charges the real cost comes to about $300 for both supplements, so I'm going to try to go without it for a while."

5 Expensive Products Not Worth the Money (and What I'd Buy Instead)

Allie Glines

829k subs

✓Yay

"I'm floored by the OneSkin OS-01 body supplement. It's an investment and packed with peptides, meant to tackle crepiness and repair the skin. Postpartum my stomach skin felt crepey, and even though they say wait six weeks, in the first few uses my skin already felt more bouncy and the crepiness was disappearing. [...] I keep seeing results so I'm not going to stop."