OneSkin OS-01 Hair Peptide Scalp Serum: a Guru Score of 84%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Dr. Sam Ellis

898k subs

✓Yay

"Once I started incorporating this, I tolerated my minoxidil so much better."

All 2 takes from Dr. Sam Ellis

My Most Purchased Haircare Products as a Hair Loss Expert | Dr. Sam Ellis

"Once I started incorporating this, I tolerated my minoxidil so much better."

Proven Treatments for Hair Thinning & Loss Besides Minoxidil | Dr. Sam Ellis

"So I have female pattern hair loss. My husband has hair shedding. [...] But this is the serum that he finds the most effective. When he was using it, he felt like his hair shedding really decreased. And when we ran out and after about a month, he felt like his hair shedding picked back up again. So this has been repurchased many times in our household."

Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Yay

"It's getting rid of those damaged, senescent cells, zombie cells, and it's making way for the good. I do [...] a droplet of this, and then this is an OS-01 peptide it's in the same thing as the best body lotion in the world. You can take a micro needling tool and roll it in, or you can stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off. So that's how protective I am of my hair."

All 2 takes from Darnell Cox | 50+ Healthy Aging Expert

Over 50 and struggling with hairloss?😰 I know first-hand how that feels

"It's getting rid of those damaged, senescent cells, zombie cells, and it's making way for the good. I do [...] a droplet of this, and then this is an OS-01 peptide it's in the same thing as the best body lotion in the world. You can take a micro needling tool and roll it in, or you can stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off. So that's how protective I am of my hair."

Over 50 and struggling with hairloss?😰 I know first-hand how that feels

"This is [...] getting rid of those damaged, like senescent cells, zombie cells, and it's making way for the good. [...] There's a lot of research on hair loss. So you do [...] a droplet of this, and then this is an OS1 peptide, it's in the same thing as the best body lotion in the world. You [...] take a micro needling tool and [...] stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off."

Beyond50Skin

32k subs

✓Yay

"They came out with this [...] at the end of the summer. And this is one of my absolute favorite adjuncts to the Rogaine. So this is a scalp serum with the OS-01 peptide that also helps with senescent cells. Skin cells are dying all over, accumulating, causing inflammation. So this helps with inflammation, also with healthy scalp. And I got through two of them, and I already have a backup."

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All 6 takes from Beyond50Skin

REAL VOLUME SECRETS FOR MATURE HAIR: Healthy Scalp & Lifting Techniques That Work After 50

"I've been using the OneSkin scalp serum. I love it. I always have a scalp serum in rotation. This is the one that I'm using right now. And I love it because it has that proprietary peptide that helps with senescent cells. Those cells are just hanging around causing trouble and inflammation."

OVER 50 SKINCARE EMPTIES: My Biggest DISAPPOINTMENTS & Instant Repurchases

"They came out with this [...] at the end of the summer. And this is one of my absolute favorite adjuncts to the Rogaine. So this is a scalp serum with the OS-01 peptide that also helps with senescent cells. Skin cells are dying all over, accumulating, causing inflammation. So this helps with inflammation, also with healthy scalp. And I got through two of them, and I already have a backup."

BEST of 2025 Skincare & Makeup for Mature Skin (50+ Beauty Picks)

"The One Skin scalp serum, number one scalp serum for 2025."

LIVE Chat: Catchup and Fall Makeup Over 50!

"I'm reviewing the One Skin Peptide Scalp Serum"

Struggling with Thinning, Dry, Grey Hair Over 50? Shampoos, Styling & Peptide Serum I’m Loving

"Once Skin has come out with their OS-01 peptide hair serum and I'm very excited to share this with you because I'm always up for new technologies in hair. I was using a growth factor serum in the past with micro needling, and I think the peptide serum is a really interesting option. The serum itself doesn't require the derma roller, you can just use the serum and get the benefit of the peptides for hair health."

Empties, Fails & Faves LIVE! Over 50 + AMAZON Beauty Prime Day Chat

"My seasonal shed was slowed down. All my hair stayed in the antigen phase so much longer. [...] I can attest that. I had not used my I just now started back on my Clesium. So it wasn't that I only used this to give it a really good solid try so that I could report back my honest feedback on the serum. Highly recommend this. And [...] if you need a new hair serum and keep your scalp healthy, keep that hair growing and not falling off your head, highly recommend this."

Allie Glines

829k subs

✓Yay

"Especially postpartum, I've been loving the OneSkin Hair Peptide Scalp Serum, using it every day for over a month. I'm starting to lose hair postpartum but so far it's not as bad [...] and I feel like it's really working. [...] It's not heavy, has no minty tingle, doesn't leave residue and doesn't weigh my hair down. It's a fabulous formula."

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All 3 takes from Allie Glines

My Absolute Faves From November 2025 😍

"I'm trying to get ahead of my hair loss this time around. I have been dousing my hair in this serum and I am really excited to see the regrowth. [...] I'm more banking on the regrowth happening. [...] The formula is great and it's something that's just easy to apply. It doesn't make my hair feel heavy or greasy because some scalp serums can be a little bit too much. It also doesn't have a tingly sensation. [...] It's a really great serum and it has really great reviews."

THE BEST HAIR, SKIN, NAILS & MORE OF 2025!

"Especially postpartum, I've been loving the OneSkin Hair Peptide Scalp Serum, using it every day for over a month. I'm starting to lose hair postpartum but so far it's not as bad [...] and I feel like it's really working. [...] It's not heavy, has no minty tingle, doesn't leave residue and doesn't weigh my hair down. It's a fabulous formula."

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"I'm really loving the Hair Peptide Scalp Serum from One Skin. It's a bit of a level up from my usual scalp treatments, but it was worth it, and [...] I've been dousing my hair with it to try to get ahead of [...] postpartum hair loss. There are other good scalp serums that aren't as expensive though."

Mixed Makeup

1.46M subs

✓Yay

"I've been using this for the last like 2 and a half, 3 months and I have seen such a huge difference when it comes to hair thinning. I have really thick hair, but up here in the front, ever since I had babies, my hair started getting a little bit more sparse. I started getting a lot of these baby hairs. [...] They just are really growing out and growing into my hair. And it's all because I've been using this. I've been doing a lot of supplements, too. That probably plays a little part in it."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Frequently asked.

What is OneSkin OS-01 Hair Peptide Scalp Serum?

A haircare serum for the scalp, built around OneSkin's proprietary OS-01 peptide and designed to support scalp and hair health.

Is OneSkin OS-01 Hair Peptide Scalp Serum worth it?

Yes. All 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 84%.

What is OneSkin OS-01 Hair Peptide Scalp Serum's Guru Score?

OneSkin OS-01 Hair Peptide Scalp Serum holds a Guru Score of 84%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 expert reviewers we have collected.