A lightweight serum containing human-derived growth factors and peptides designed to stimulate collagen and elastin production and reduce fine lines and wrinkles.
Growth factors in this serum earn consistent praise for visibly reducing fine lines and improving skin texture within weeks, with some gurus noting it helps even with deeper wrinkles and subtle sagging. The tradeoff is steep: at $295, it's positioned as a splurge for those committed to anti-aging, and while devotees swear by it, one dermatologist remains skeptical that topical growth factors deliver more than basic moisturizing. Those with mature skin or rosacea-prone skin may want to patch test first, though reviewers found it surprisingly calming rather than irritating.
Synthesized from 10 expert reviews · most recent take August 2026
"TNS, that TNF alpha growth factor serum, was one of those medical grade products that got really popular, and [...] a lot of derms were sold on it, saying that stuff was legit. But I was like, no, there's no way this is working. Growth factors put on the skin are not going to do anything above and beyond maybe moisturizing the skin, and I don't think they're worth spending a lot of money on."
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"That said, you will find SkinMedica TNS serum users out there who will cut your throat if you take that stuff away from them, so clearly it does something for some people. Is it going to do anything for you? I don't know, and the reason I don't know is not because I'm an idiot, it's because we don't have good data to predict who's going to respond to these things and who's not. You've got to stay consistent with something like this in order to begin to turn a corner and see meaningful change."
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"TNS, that TNF alpha growth factor serum, was one of those medical grade products that got really popular, and [...] a lot of derms were sold on it, saying that stuff was legit. But I was like, no, there's no way this is working. Growth factors put on the skin are not going to do anything above and beyond maybe moisturizing the skin, and I don't think they're worth spending a lot of money on."
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"Even though the SkinMedica TNS Serum does have fragrance in it, they actually conducted pilot studies showing that it improves the signs of aging."
"I love this stuff. It's got their human fibroblast conditioned media, which they have a proprietary interest in and have been using in this serum for a very long time. It is amazing, for me it's worth it. I use it very sparingly, just around my eyes and around my mouth, so I can make a bottle last three or four months. At Dermstore sometimes there are good sales, so it might be worth checking out. Love it, good product."
"This is one of few products that really has helped me with my skin hugely. Between this, vitamin C, and a good sunscreen, it's really helped my skin a ton. Fine lines are less noticeable, skin just looks smoother. I'm impressed with this stuff."
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"If you're going to spend that much money, [...] I would recommend the SkinMedica TNS Advanced+ Serum. [...] That one offers more benefits and better ingredients. [...] It doesn't have the fragrant essential oil in there either. The nice thing is it's friendly for acne-prone skin. [...] I love the texture of it, feels nice, but at this price I expect a little more, maybe a little more peptides or maybe some growth factors or something. It's not bad, it's just I won't repurchase it."
"This expensive one, the SkinMedica TNS Advanced+ Serum -- so expensive. I did a lot of research because I kept thinking I need to buy a backup because this one's getting low; I've been using it a lot lately. I looked at like a million websites -- Dermstore, Derm Avenue, Editor's Pick, Lovely Skin, RX -- [...] and I haven't decided yet. But [...] I mentally can't pay over $200 for it at this point."
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"I really love the SkinMedica TNS serum but I really got tired of paying $300 and then feeling guilty when I used it or guilty when I bought it because that's a ridiculous amount of money. I didn't at first love this ingredient, growth factors, epidermal growth factors, because there's not like 20, 30 years of studies on the safety of it."
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"The winner for favorite luxe skincare product of the year is -- you guys guessed it, I know you did because you watch a lot of my videos -- it's the SkinMedica TNS Advanced+ Serum, which is coming out with new packaging this year. Hopefully they don't raise the price. Fingers crossed, because I can't afford much more."
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"It's one of the few products that really helped with a dull appearance and the appearance of fine lines and wrinkles within about a week, even a couple of days. This is one of [...] a handful of products that have been total game changers for me. [...] Their human fibroblast conditioned media is the real deal. It's fragrance free, lightweight, gel texture, and allows layering. The packaging is the major bummer. The product itself is great but the packaging sucks; they could use a revamp."
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"This is an expensive one. [...] If you can get on sale it's a deal, but I will never pay the market price for this. I will only buy it if it's a really good sale, lots of cash back, and a good gift with purchase because otherwise it's just so expensive. Revive serum has something that's very similar and it's one-third of the price."
"The SkinMedica TNS Advanced+ Serum is an amazing product. If you use it for a week, it's hard not to notice the results. I've tested a lot of products that have similar ingredients, but this one really stands out. The packaging is quite nice, the size is large at 1.69 ounces, and the texture is quite nice with a gel texture to it. I've been pretty impressed with it."
"It's got a creamy texture with all those nice growth factors and anti-aging ingredients in here, which there's only a handful of products that really make a difference that I could tell using them, and SkinMedica was one of them."
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"It appears as though they're not going to get rid of the dual chamber system, but they are going to upgrade it so it's more functional. [...] This is a big bulky container and I hate the fake metal because that starts to chip off. [...] The dual chambers can be really annoying. I've read though if you store it upside down that helps it dispense better. [...] There's little holes, and if you have an issue, you can use a paper clip and jam it in there."
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"Once I add this into my routine it's one of the few handful of products that I could tell a difference in my skin within a week or less. [...] This one uses their human fibroblast conditioned media they have a trademark on it, it also contains peptides and botanicals, great for anti-aging skin renewal. Certainly made a huge difference in my fine lines, noticeable difference. But it's $295 which is really expensive, so [...] it's worth buying it on sale."
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"I love this. It's great for dry skin. I use it a lot at night, [...] on my neck, and even on post-procedure skin because it has all the nice rejuvenating ingredients as well as the anti-aging ingredients. [...] You can get some of that human fibroblast conditioned media at a more affordable price point with this one. The packaging changed and I'm not sure how I feel about it, though I didn't love the old packaging either. [...] This one helps fight wrinkles, especially [...] around the eye area."
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"There's certain products that I will say I have used within a couple days I noticed positive results. It's probably three products. Uh Geek and Gorgeous Apad, Geek and Gorgeous Seaglow, and the SkinMedica TNS serum. That's it."
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"SkinMedica TNS Advanced Serum. [...] The pumps are annoying because they don't dispense at the same time. So like the first five uses of it, you're just using one of the two serums and it's really annoying. It's wonderful."
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"It's one of a handful of products where I've used it and almost the next day I could tell my skin look better and smoother and things like that. This is definitely probably the number one pick I really enjoy it. It's fragrance free. The dual pump is kind of annoying sometimes, not quite even, but they've got two holes here so if one of them gets off track you just stick like a paper clip in there and you can even it out. This has to be my number one pick. It's really nice."
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"This stuff is wonderful. It contains their personally made human fibroblast conditioned media, it also contains the praline peptide and whey protein. The pump is a little annoying because you can see how it has two little holes there, one part has half of the ingredients in and the other one has the other half of the ingredients, so you really want both of them to dispense at the same time to get your bang for your buck. It is a game-changing product."
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"The SkinMedica TNS serum is amazing and it's super expensive. I still love it. There's a lot of good dupes for it but still really wonderful, but it's so expensive. If I could take one expensive product that would probably be it."
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"I love this product. I've repurchased it many times. It happens to be easily the most expensive one out of all of them. But I don't typically use it all over my entire face. I typically focus on certain [...] areas where I get fine lines, around my mouth and around my eyes, a little bit on the forehead and right in the middle between my eyebrows. [...] A bottle of this will [...] last me three or four months with very conservative usage of it. So it doesn't seem as expensive."
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"I like to use this one because it's got some really good growth factors in there. It's really great for anti-aging, but it's too good to waste any of it."
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"The SkinMedica TNS serum is really good. It's got the human fibroblast condition media. It's more expensive, about three times the price of some alternatives, and it's almost half the size, but it's really good. I've repurchased it a couple times at least, and I most products I don't repurchase unless I really really like them and I'm committed to continuing to use them."
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"It's expensive but [...] this one uses their brand's proprietary human fibroblast conditioned media, which is why it is so expensive. This is one in a handful of products where two, three days in, I did notice a difference for me, especially around my eyes."
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"I've been obsessed with the SkinMedica TNS serum which is upwards of $300 a bottle. I've loved the SkinMedica TNS serum, it's upwards of $300. I've repurchased a couple times, but I got really good deals. When I use that within a couple days it's like an amazing difference on my skin. I'm always on the hunt for the next best thing because of that same feeling."
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"This is one product where I applied it to my skin and within two or three days I noticed my skin looked softer and smoother, and lines looked less apparent. The star of the show is their human fibroblast conditioned media, which encourages skin cell renewal and supports collagen and elastin levels, revealing a smoother, more radiant, and youthful complexion. It also contains dimer tripeptide-43, grape flower seed extract, and whey proteins."
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"This stuff is it it's one of the few products I also say along with the geek and gorgeous zad serum or it's something like instant results amazing like you could tell the difference"
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"It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, but you can make this one last a long time. I probably been working on this specific bottle for four months with probably another month in it, so just using it sparingly where my wrinkles are. I don't use it everywhere, I just focus on the areas where there's wrinkles."
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"The closest I've gotten so far to an all-in-one product is the SkinMedica TNS Advanced+ Serum, which we all know is very freaking expensive, but for me, that's the closest I've gotten to it."
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"I've tested both of these. For the price, I've just found comparingly that the SkinMedica TNS Advanced+ Serum is more beneficial -- more efficient, more effective for me. Maybe for some people the alternatives will be better, but I [...] found the SkinMedica to be one of the most efficient, effective anti-aging products out of all of them."
"It's got the SkinMedica patented human growth factor complex, it's also got prolene peptide as well as a milk peptide complex for anti-aging and collagen production in skin. It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, if it's too expensive I totally get it, [...] but you can make this one last a long time. I make this bottle last a long time too."
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"The SkinMedica TNS Advanced+ Serum is another one of a handful of products -- maybe 10 in my life -- that have been near-instant game changers. It's $300, though."
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"Within two or three days of using the SkinMedica TNS serum, the difference I noticed in my skin was hard to deny that it was beneficial. Growth factors have undeniable results for me when using a growth factor serum."
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"This stuff is a handful of products that I start using and within days my skin just looks and feels so much better. I love it."
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"SkinMedica's got a reputation with their growth factors that go back several years and they've cultivated it in a certain manner and function. I love this product absolutely. If you can get it on sale, that's something to consider, because it is expensive, about two and a half times the price of comparable products, though it still has a lot in it."
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"It really helps with fine lines and wrinkles. If you're super young you probably don't need it, but once you start getting a little older and start to notice wrinkles, fine lines, a little bit of sagginess or droopiness, seriously, within a couple nights this stuff does make a huge difference, at least it has for me and a lot of other people. It gives skin a nice plumped appearance, firmer, and wrinkles look a little less noticeable."
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"It's really nice lightweight serum. [...] This is one of a few [...] holy grail products for me. [...] Within a few days my skin really started to look better to me. The [...] human fibroblast condition media stimulates elastin and collagen production deep down in skin which helps with fine lines, wrinkles, and saginess. Enhances wound healing especially after treatments like micro needling or lasers. Reduces redness and dryness as well as transepidermal water loss."
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"I'm addicted to it. I love it. It's so expensive, but I do feel like I can tell a difference in my skin when I stop using it. And when I first started using it, I could tell the difference."
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"The SkinMedica TNS Advanced+ Serum is one of the few products I've used where I've noticed a dramatically different appearance of my wrinkles after using it. It just makes a huge difference in my skin. There's not a lot of products I can say made a noticeable difference like within a day or two, and this is one of them. They could charge even more and I'd probably still repurchase it."
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"The SkinMedica TNS Advanced+ Serum, this one's upwards of almost 300 bucks if you can get it on sale it might be worth it. Occasionally there's a good sale typically around the holidays and I'll be able to get it for like 100 to 150 bucks, but that's typically not often. Although right now it's on sale at Derm Store, I think it's like 70 bucks off, so if you're looking at it it might be a decent time to buy it, but still pricey."
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"The SkinMedica TNS Advanced Serum is $295. It's one of the few products where I can notice results quite quickly. If I stop using it for a while and I start using it again, I'll notice the results again really nicely. It has great growth factors in it, really nice in terms of antioxidant protection for fine lines and wrinkles."
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"This is a great, very nice moisture texture to it. If you use it at night time, it's really nice. If you've got dry skin, or during the winter if your skin gets really dry, you can also use it in the daytime as well. It is on the thicker side. Their advanced serum is wonderful. I'm working on a video where I'm comparing all of their TNS products."
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"The SkinMedica TNS serum was huge for me. I love that stuff. It's so expensive, but [...] I use it super sparingly. I use it on my forehead, a little bit around my eyes, and around my mouth. I don't really use it anywhere else. Using it on dry skin or right after a mist helps it absorb quicker. A bottle of it will last me six or seven months just using it very, very, very sparingly on those couple areas."
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"This is probably a little bit better than their previous packaging, but still not much of an upgrade in my opinion. But I love the product. It's amazing. It's one of the sole products that really makes a noticeable difference in fine lines and wrinkles, and it's a game changer."
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"But I love this stuff. This is something that I don't want to have to compromise on. I don't see myself taking these out for my routine anytime soon because it's really a work horse. It really helps with fine lines and wrinkles, and I can notice it when I stop using it for a week or two, to when I start using again. I can notice a difference. So, it's amazing. There's not a lot of skincare products that are like within a couple days you notice a difference. It's amazing the difference it makes."
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"Even my dad noticed, which was amazing because he doesn't notice much. I added it in without really having to sacrifice anything, change anything else, or have to deal with irritation. The SkinMedica one is very expensive, it's about $300, but it is an absolutely amazing ingredient that when you add it to your routine, I think if you have some signs of aging you will notice a radical difference very quickly."
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"They use human fibroblast conditioned media and this is one of a handful of products where I used it and within a few days I noticed my skin look better. There's not a lot of products that I can say that about."
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"I love this stuff. [...] It's expensive, but if you're going to be into this one you've got to learn to watch for sales because when you can get on sale it saves a lot of money really fast. [...] The thing is that around the metal of this it starts to flake off and starts to get on your face, which is not a good look, but [...] I need to repurchase it."
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"I love peptides. I love growth factors. [...] They're great for helping deep down in your skin, renew it, soothe it, help with collagen production. The SkinMedica TNS Advanced Serum is one of my favorites. This stuff's really nice."
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"The SkinMedica TNS Advanced+ Serum, I just love this stuff. It sucks because it's so expensive, but it really is a game changer. This contains their proprietary formula of human fibroblast conditioned media cells which helps with collagen production and increase in plumpness in skin, and it is noticeable within a few nights to a week or two. It's amazing."
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"The SkinMedica TNS Advanced+ Serum is one of the two products I've noticed work the fastest with the fastest results. Almost nothing can deliver that fast, but even this product is a couple weeks or a week or two before I noticed a difference. It's got [...] no denaturating drying types of alcohol, which is nice for sensitive skin. [...] There's no fragrance ingredients and no noticeable scent, which is also very nice for sensitive skin. The manufacturing location is the US."
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"I love this serum, it's so wonderful. The star of the show for this one is human fibroblast conditioned media, a proprietary ingredient made by SkinMedica that works as a cell signaling molecule to stimulate cell growth, proliferation, and healing. [...] There's a handful of products where I've used them and within a day or two I have noticed benefits, and there's not a lot of them, because most products require you to be on top of it, require consistency, require patience."
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"I love this stuff. It's got their human fibroblast conditioned media, which they have a proprietary interest in and have been using in this serum for a very long time. It is amazing, for me it's worth it. I use it very sparingly, just around my eyes and around my mouth, so I can make a bottle last three or four months. At Dermstore sometimes there are good sales, so it might be worth checking out. Love it, good product."
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"My favorite growth factor product is the SkinMedica TNS Advanced Serum. It's got SkinMedica's proprietary human fibroblast conditioned media. It's one of the products I've noticed to be most beneficial for my skin care. This one's just a really great serum, I use it very sparingly."
"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
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"Growth factors are one of the categories where formulation, stability, and delivery really do matter, which is why this is an area where splurging can make sense. Growth factors help support skin repair, regeneration, and overall skin resilience. They don't replace retinoids, but they do work alongside them to improve skin quality, especially as skin ages. It's one of the options I trust clinically."
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"Some of my favorite growth factors are the SkinMedica TNS Advanced+ Serum. Growth factors are signaling molecules that can help increase collagen production like retinoids can but they aren't as irritating to the skin like retinoids might be. [...] You'll want to apply your growth factor serum as the first step after you wash your face in both the morning and the evening."
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"My favorite supportive products for the jawline and neck include Skin Medica, the TNS Advanced Plus Serum"
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"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
"You will find this peptide in the hugely popular SkinMedica TNS serum, which is kind of an expensive product, so you're paying for a premium, but it's a cult favorite and it's widely loved by the people who use it frequently. This is really for skincare enthusiasts who want to try cutting edge ingredients and don't mind paying for that, even if the science isn't quite there yet."
"This isn't for me; it's not in my budget, [...] and I don't want to be investing in this product at the expense of other steps in my routine. It just doesn't align with my individual budget. That doesn't mean it's not great; it is. Because these are actually human-derived growth factors, you're probably going to see some very quick results, and [...] some next-level results when it comes to anti-aging. For me, I just think there are some ethical considerations at least to think about here."
"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and [...] it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin."
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"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and [...] it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin."
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"SkinMedica TNS Advanced+ Serum is clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. The dual growth factor system stimulates the collagen and elastin production. It's really lightweight, super fast absorbing formula designed for that really mature aging skin. The key ingredient here is the TNSMR, the blend of growth factors and peptides. It also has the Renaissance complex which is the botanicals and marine extracts."
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"Another one that's really popular is the Skin Medica TNS Advanced Plus Serum. This is human derived, the clinical standard, but it's significant splurge."
"It was extremely popular amongst physicians, probably 5 to 10 years ago. I haven't heard much about it lately, I haven't really heard anyone talking about it lately, but it does definitely have a cult following and it has a plethora of clinical data around it to support its efficacy. This one is derived from humans, specifically the foreskin. I haven't personally tried it, but it definitely has a cult following."
"It's from SkinMedica. Their TNS Advanced+ Serum certainly is not cheap. It retails for $295, but the formulation as well as just the level of evidence and clinical studies, really no other product can beat that."
"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, [...] but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, [...] but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"I'm talking about SkinMedica's TNS Advanced+ Serum. These can help to stimulate fibroblast to produce more collagen and elastin and to help reduce crepiness and laxity overall. You can use it longer term for your neck and your chest. It will take longer for you to see full results, but you can absolutely use it. If you combine it with in office procedures, you will see results more effectively."
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"SkinMedica TNS serum has growth factors, cytokines, and Matrix proteins that people swear by. This is a particular product I recommend for patients who cannot tolerate retinols on their neck even though they try to buff it with a moisturizer. I tell them just go for this for your neck or those hard to reach areas. It's a great adjunct to have."
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"This is tried and true and yes it is expensive, but this has EGF, TGF beta, and FGF, okay? And they're all human derived. It means human skin was put in a culture medium and that culture medium was then taken, filtered, sterilized and stabilized and you're getting that and that's what you're applying on the surface of your skin. This works best for deep wrinkles, elasticity. I love it post-procedurally after micro needling, any type of radio frequency with micro needling, any type of frail."
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"SkinMedica has their TNS Advanced serum. You can use this from here to here, you will not get irritated on your neck, unlike if you use a retinol on your neck and chest where most of you will get irritated. [...] You can even find hexapeptide-2, which helps with fine lines in the active seal. So there's vitamin C, peptides, and moisturizer, also ceramides in this. This is purely growth factors and peptides in here."
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"SkinMedica TNS Advanced Serum is a blend of growth factors, cytokines, and matrix proteins that can stimulate fibroblasts, which are the cells responsible for producing collagen, to increase collagen synthesis. It's [...] pricey, but if you've tried all the rest and feel like you need more, venture into this. If you want something for your neck and chest and you've never been able to tolerate a retinol but you want something more than coenzyme Q10, [...] try this, it definitely helps."
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"It comes in a dual chamber pump and you get two types of serums that get pumped out of it that you mix together when you apply it. There is a very light scent to it, just beware because it does pill over other products that have actives. I personally use this at night on my face, neck and chest. I actually use this exclusively on my neck and chest on most nights because my neck and chest cannot always tolerate a retinol and sometimes it gets irritated."
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"This is one that I recommend especially for people as they approach their 40s who cannot necessarily tolerate retinols or who are looking for an adjunct to their retinols. [...] I love this particular product for the neck especially, because most people cannot tolerate a retinol on the neck. [...] Even though it is very pricey, [...] it comes in a very lightweight serum, it does smell slightly funky, but good skincare doesn't necessarily always smell like roses."
Best Products & Treatments for Your Neck! | Dr. Shereene Idriss
"SkinMedica TNS Advanced Plus Serum is an interesting product despite how expensive it is. [...] For $295 it's steep, but it combines growth factors and peptides. It has two [...] chambers: the TNS chamber [...] contains human fibroblast conditioned media and patented growth factor formulation to stimulate cell growth and help with fine lines, wrinkles, tone and texture, plus peptides like preline and [...] prolixa 20."
Dermstore Black Friday Sale Top Picks 2021! | Dr. Shereene Idriss
"SkinMedica TNS Serum has all of the human growth factors in it to help give you fetus-like skin. I will say that it smells bad and it is a little bit odd in texture. But if you're really searching for that fountain to help with your skin and you can't tolerate a retinol, it might be worthwhile trying out."
"It's one of the only growth factor products on the market that has actually proven to help with collagen production and elastin and help with fine lines. But it's definitely more of a splurge product."
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All 6 takes from Dr. Sam Ellis
Dermatologists' NO FAIL Anti-Aging Skincare Routine | Dr. Sam Ellis
"This has good clinical data showing it helps with fine lines, wrinkles, and even skin sagging. There's not a lot in skincare that helps with sagging. It's not going to lift your jowls up, but for people who apply it to their neck or around their eyes, they do notice noticeable improvements. This is just a product I really enjoy using. As someone with rosacea and more reactive skin, I also find it quite calming and not irritating. I'm a big fan."
Finally Releasing My BEST Cash Saving Beauty Tips! | Dr. Sam Ellis
"It's one of the only growth factor products on the market that has actually proven to help with collagen production and elastin and help with fine lines. But it's definitely more of a splurge product."
Anti-Aging Skincare Products Worth EVERY SINGLE PENNY | Dr. Sam Ellis
"The SkinMedica TNS Advanced+ Serum is a combination growth factor peptide serum that is a Holy Grail for so many people who take their anti-aging game very seriously. You would apply it to your bare clean skin ideally twice a day, and it's been shown to help with fine lines and wrinkles, but it's also been shown to help with sagging."
Dermatologist Shares Why Expensive Skincare Might Be Worth It | Dr. Sam Ellis
"This particular growth factor serum by SkinMedica is probably the most studied growth factor serum on the market, and it has been shown to help with things like skin sagging as well as improving fine lines and wrinkles. This retails for almost 300 dollars, and with tax it's over 300 dollars."
Best Anti-Aging Skincare Ingredients to Add to Your Skincare Routine (Wrinkles, Dark Spots, & More)
"The most popular growth factor product and for good reason is the one by SkinMedica, their TNS Advanced Serum. This product has great data behind it, but you know it's also a big investment. This product has actually been shown to lift sagging skin and there's not a lot out there that can help with increased skin laxity and skin sagging when it comes to skincare, and I think that's why a lot of people gravitate towards it is because of its tightening abilities."
Dermatologist Reviews the Anti-Aging Serum Everyone’s Talking About | Dr. Sam Ellis
"The SkinMedica TNS Advanced Serum is one of the two serums I would really recommend if you're going to invest in growth factors because it's the most studied and has actually shown clinical improvements in human subjects. It will run you about $300, and it has shown to lead to skin improvements including thickness of skin, better tone in skin, more evenness in skin, and it contains human-derived growth factors, which is the creme de la creme."
What the evidence says.
Independent of what the gurus think, this is what
the published research supports about the main active ingredients here.
Vitamin E
Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.
A lightweight serum containing human-derived growth factors and peptides designed to stimulate collagen and elastin production and reduce fine lines and wrinkles.
Is SkinMedica TNS Advanced+ Serum worth it?
The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.
What is SkinMedica TNS Advanced+ Serum's Guru Score?
SkinMedica TNS Advanced+ Serum holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 expert reviewers we have collected.
Who is SkinMedica TNS Advanced+ Serum best for?
SkinMedica TNS Advanced+ Serum is generally suited to mature skin.
Cheaper alternatives the gurus rate.
Lower-priced serums the gurus still rate highly, versus this luxury pick.
