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Timeless

Timeless Matrixyl Synthe'6 Serum.

About this product

A hydrating serum that combines Matrixyl Synthe'6 peptides with hyaluronic acid, designed to hydrate and support the look of firmer, plumper skin.

Full ingredients

Water, Glycerin, Aloe Barbadensis, Sodium Hyaluronate, Benzyl Alcohol, Dehydroacetic Acid, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38

More from Timeless 12 products · Guru Score 96% →

Guru Score

76%

Yay

6 experts · Moderate agreement

What the gurus are saying

Hydration with a peptide bonus is what keeps coming up for this serum, with its Matrixyl Synthe'6 peptides added to a hyaluronic acid base. Many gurus like its texture, and pairing it with retinol or tretinoin is suggested for extra benefit. The one thing to keep in mind: some doubts remain about whether it stands apart from other serums, so anyone hoping for a big peptide jump may want to set expectations.
Synthesized from 6 expert reviews · most recent take June 2026

What they liked

  • Lightweight, runny texture, easy to apply
  • Very hydrating without feeling heavy
  • Pairs well with retinol and tretinoin

What they flagged

  • Results unclear compared to simpler serums
  • Not always easy to find in stock

Best for

Type

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Darnell Cox | 50+ Healthy Aging Expert
Darnell Cox | 50+ Healthy Aging Expert
55k subs
✓Yay
"Timeless makes a stronger one than this, and it's called Timeless Skincare Matrixyl Synthe'6 Serum."
Doctor Anne
Doctor Anne
56k subs
✓Yay
"The Timeless Matrixyl Synthe'6 Serum is hydration with added peptides from the matrixyl complex, which I enjoy. I have other serums [...] I use for my peptide fix, so I like this for hydration with some peptides extra. [...] It isn't as easy for me to get as other ones and it's in the medium price range, but the Timeless range is quite nice if you want a hydration plus peptide serum and don't want to invest in copper peptides."
All 3 takes from Doctor Anne
I Used Up ALL of These in 2025 - Skincare, Hair & Makeup Empties | Doctor Anne
"The Timeless Matrixyl Synthe'6 Serum is hydration with added peptides from the matrixyl complex, which I enjoy. I have other serums [...] I use for my peptide fix, so I like this for hydration with some peptides extra. [...] It isn't as easy for me to get as other ones and it's in the medium price range, but the Timeless range is quite nice if you want a hydration plus peptide serum and don't want to invest in copper peptides."
My 2025 winter morning and night time skincare routine | Doctor Anne
"I follow up with a second serum, the Timeless Matrixyl Synthe'6 Serum. The added peptides obviously won't hurt, but it is the hydration I am mainly after."
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"Synthe'6 is another peptide from the Matrixyl complex, the name kind of gives it away, it's supposed to synthesize six important parts of the skin structure like collagen, elastin, and other things. Again it's Matrixyl but not the same as Matrixyl 3000, and it's a hyaluronic acid serum with some extras, perfect for those like myself who are on the more mature side and want to add hydration but with a bonus."
HotandFlashy
HotandFlashy
1.23M subs
✓Yay
"I love their Matrixyl Synthe'6 Serum."
All 14 takes from HotandFlashy
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"I love their Matrixyl Synthe'6 Serum."
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"The next thing I go in with is my Timeless Matrixyl Synthe'6 Serum. Matrixyl Synthe'6 is supposed to help with six different signs of aging. I use about a half a dropper of this and I just put this generously all over my face, all over my neck, I put it on my eyelids, on my upper lip, on the backs of my hands, and on my chest."
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"I apply my Timeless Matrixyl Synthe'6 Serum, this is a peptide serum. The matrixyls help with varying signs of aging so they'll help with wrinkles, they'll help with discoloration, so help with all kinds of things. They're very hydrating."
Winter Anti-Aging Skincare Routine Update! Over 40, 50, 60+
"The Timeless Matrixyl Synthe'6 Serum is a nice clear runny liquid. I just put on about a half a dropper of this, rub it along, rub it all over my face and all over my neck. Matrixyl Synthe'6 is another peptide that hits six different signs of aging and it helps your skin to produce more collagen and helps to reduce your wrinkles."
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"I also use the Timeless Matrixyl Synthe'6 Serum. This is another peptide and this peptide is supposed to affect your skin in six different ways or to reduce six different signs of aging."
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"The fourth Timeless product that I use is the Matrixyl Synthe'6 Serum. This is another peptide serum. I love their formulas because they have a very small ingredient deck. There's not a lot of fluff in here, there's not a lot of extra ingredients, you know, botanicals that are going to bother your skin. They're formulated properly, which is very very important."
SKINCARE Products I USED UP! | Face & Body Skincare Empties 2025
"The second thing that I put on after that at night is my Timeless Matrixyl Synthe'6 Serum. This is another matrixyl but this one helps with six different signs of aging. This one is supposed to help with synthesis of collagens types 1, 3, 4, fibronectin, lamins, and hyaluronic acid. So this is another great peptide that has been shown to work in the skin. Very lightweight, fluid serum that's easy to apply."
Trash or Treasure? Reviewing Products I've Used Up! Makeup, Skincare, Beauty
"I love this serum, it's been a Holy Grail for me for years now. Matrixyl is a peptide and it's supposed to work on six different signs of aging in your skin and I use this one in my nighttime skincare routine. I love it. I usually buy the 4 oz version of this and just decant it into this little bottle."
Skincare Empties | Skincare for Collagen + Menopausal Dry Skin!
"The next one is the Timeless Matrixyl Synthe'6. This is another peptide. Matrixyl Synthe'6 hits six different signs of aging, so it's supposed to help with building collagen, building elastin, reducing your wrinkles, reducing your age spots, making your skin look plumper and firmer. This one is clear and just a little bit thicker than water. It goes on your skin, it hydrates. I love this one too."
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"This Matrixel Sin 6 serum contains 2% Matrixel Sin 6. And this one is also kind of a double duty product because you do get the CoQ10 in there."
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"The next thing I put on is my Timeless matrixyl syn6 serum no change there."
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"I also love the Timeless Matrixyl Synthe'6 Serum. This goes in my nighttime routine. I put this on right after my retinoid."
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"I love the Matrixyl Synth-6 serum."
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"Then the next serum I put on is my Timeless Matrixyl Synth 6 serum. This fights six different signs of aging. It is a really watery lightweight serum. I just put a few drops in my fingertips and I rub it all over my face, all over my neck, my eyelids, my lips."
Mad About Skin
Mad About Skin
731k subs
✓Yay
"I've been using the Timeless Matrixyl Synthe'6 Serum on and off for the past 2 years and it's wonderful. This has fewer peptides in than some of the other formulations that I'm sharing with you today but it has some of the very best plumping and hydrating ingredients you're going to find. If you're someone that wants your peptides with a plumping fix, I think the Timeless Matrixyl Synthe'6 Serum is one of the best on the market."
Dr Dray
Dr Dray
2.69M subs
✓Nay
"This has matrixyl synth prime 6, a different synthetic peptide from matrixyl 3000, along with glycerin and hyaluronic acid. It tolerated fine for me, no irritation. But to what extent it's going to offer strikingly different results from some of the other serums, I'm not convinced, so this one for me is one I would not repurchase."
All 2 takes from Dr Dray
Vlog: SKIN CARE ROUTINE USING TIMELESS SERUMS 😊 @DrDrayzday
"I'm coming in with a few drops of the Timeless Matrixyl Synthe'6 Serum, trying to make my way through it. This one of the Timeless serums is interesting, but I would not repurchase it personally. [...] As a serum it definitely has a nice consistency and it's super hydrating, similar to the Q10 one. There are plain hyaluronic acid serums out there that are more costly than this and don't have as nice of a consistency."
DERMATOLOGIST REVIEWS TIMELESS SKINCARE SERUMS @DrDrayzday
"This has matrixyl synth prime 6, a different synthetic peptide from matrixyl 3000, along with glycerin and hyaluronic acid. It tolerated fine for me, no irritation. But to what extent it's going to offer strikingly different results from some of the other serums, I'm not convinced, so this one for me is one I would not repurchase."
Sincerely Miss Ash
Sincerely Miss Ash
195k subs
✓Yay
"I really like the Matrixyl Synthe'6 from Timeless because this is more for accelerated signs of aging. This actually does help to firm the skin, soften fine lines, and to stimulate new collagen. It contains a powerful polypeptide, but there's also hyaluronic acid in here which helps to hydrate and plump the skin. And this is fabulous just on its own, but it works even better when you pair it up with your retinol or tretinoin. The pairing is absolutely fabulous."
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All 7 takes from Sincerely Miss Ash
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"I really like the Matrixyl Synthe'6 from Timeless because this is more for accelerated signs of aging. This actually does help to firm the skin, soften fine lines, and to stimulate new collagen. It contains a powerful polypeptide, but there's also hyaluronic acid in here which helps to hydrate and plump the skin. And this is fabulous just on its own, but it works even better when you pair it up with your retinol or tretinoin. The pairing is absolutely fabulous."
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"I love Matrixyl Synthe'6 because it really does firm the skin."
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"It's super hydrating, it never pills with other skincare products. You can use this paired up with your retinol at night time or tretinoin, or you can also use this in the morning if you wish, up to twice a day. Once a day is honestly sufficient enough, but if you want to use this twice a day, go for it. [...] It's a peptide, it's not going to be irritating on the skin, at least for most people. It's a great product to use to firm the skin. It can also help to stimulate new collagen as well."
RESULTS GUARANTEED! 10 PRO TRETINOIN/RETINAL PAIRINGS TO LIMIT SKIN IRRITATION AND SIGNS OF AGING
"I really like the Timeless Matrixyl Synthe'6 Serum. This is a great peptide serum to incorporate before your tretinoin or of course before your retinal because peptides really help to firm the skin and they can really give more of that youthful look to the skin with consistent use. I love pairing up peptides with tretinoin and I just think that is one of the best pairings you can do for signs of aging and to firm up the skin."
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"I really like the one from Timeless, this is the Matrixyl Synthe'6, so this contains several types of peptides and this would be more for those that are experiencing accelerated signs of aging so you're noticing that loss of firmness, your skin isn't as tight as it used to, maybe you are starting to notice fine lines and wrinkles then I would say go with this over just regular Matrixyl or Argireline."
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"I really like this one more so over the Timeless Matrixyl 3000. Now Matrixyl 3000 is very similar to this, it's peptides, but Matrixyl 3000 is more for those that are starting to see early signs of aging, or maybe you haven't seen it yet but you want to prevent it. The Matrixyl 3000 would be the serum that I would go with. If you're starting to experience more accelerated signs of aging, loss of firmness, fine lines, then I would say go with the Matrixyl Synthe'6."
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"I love the Matrixyl Synthe'6 since it's definitely underrated and I think you should try this at least once. You can use this prior to tretinoin or retinol, or you can just use this on its own and use this every day twice a day if you wish to. This is also another great alternative option if you're someone that can't use vitamin C or retinol, this would be like the next best thing to use to target signs of aging."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Timeless Matrixyl Synthe'6 Serum?

A hydrating serum that combines Matrixyl Synthe'6 peptides with hyaluronic acid, designed to hydrate and support the look of firmer, plumper skin.

Is Timeless Matrixyl Synthe'6 Serum worth it?

Mostly yes. 5 of the 6 gurus who reviewed it give it their stamp of approval, for a Guru Score of 76%.

What is Timeless Matrixyl Synthe'6 Serum's Guru Score?

Timeless Matrixyl Synthe'6 Serum holds a Guru Score of 76%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected.

Who is Timeless Matrixyl Synthe'6 Serum best for?

Timeless Matrixyl Synthe'6 Serum is generally suited to mature skin.

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